Schumacher Lab Publications

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Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY.
Geroscience. 2024 Jun 20.
https://doi.org/10.1007/s11357-024-01232-x. Online ahead of print.
PMID: 38900346

Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging

Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B.
Nucleic Acids Res. 2024 Jun 19:gkae519.
https://doi.org/10.1093/nar/gkae519. Online ahead of print.
PMID: 38894680

Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence

Siametis A, Stratigi K, Giamaki D, Chatzinikolaou G, Akalestou-Clocher A, Goulielmaki E, Luke B, Schumacher B, Garinis GA.
Nat Commun. 2024 May 14;15(1):4061.
https://doi.org/10.1038/s41467-024-48443-6.

Aging clocks based on accumulating stochastic variation.

Meyer DH, Schumacher B.
Nat Aging. 2024 May 9. doi: 10.1038/s43587-024-00619-x. Online ahead of print.
PMID: 38724736

DNA repair deficiencies and neurodegeneration.

Ropert B, Gallrein C, Schumacher B.
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.
PMID: 38640601

Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage

Arvanitaki ES, Goulielmaki E, Gkirtzimanaki K, Niotis G, Tsakani E, Nenedaki E, Rouska I, Kefalogianni M, Xydias D, Kalafatakis I, Psilodimitrakopoulos S, Karagogeos D, Schumacher B, Stratakis E, Garinis GA.
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2317402121. doi: 10.1073/pnas.2317402121. Epub 2024 Apr 18.
PMID: 38635632

Genome Instability and DNA Repair in Somatic and Reproductive Aging.

Panier S, Wang S, Schumacher B.
Genome Instability and DNA Repair in Somatic and Reproductive Aging.
Annu Rev Pathol. 2024 Jan 24;19:261-290. doi: 10.1146/annurev-pathmechdis-051122-093128. Epub 2023 Oct 13. PMID: 37832947

baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism.

Gallrein C, Williams AB, Meyer DH, Messling JE, Garcia A, Schumacher B
baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism.
Cell Rep. 2023 Dec 26;42(12):113577. doi: 10.1016/j.celrep.2023.113577. Epub 2023 Dec 14.
PMID: 38100354

Chronic kidney disease promotes ageing in a multiorgan disease network

Benzing T, Schumacher B.
Nat Rev Nephrol. 2023 May 26.
doi: 10.1038/s41581-023-00729-6. Online ahead of print.

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