Publications by Schumacher Laboratories

Braun F, Mandel AM, Blomberg L, Wong MN, Chatzinikolaou G, Meyer DH, Reinelt A, Nair V, Akbar-Haase R, McCown PJ, Haas F, Chen H, Rahmatollahi M, Fermin D, Ebbestad R, Slaats GG, Bork T, Schell C, Koehler S, Brinkkoetter PT, Lindenmeyer MT, Cohen CD, Kann M, Unnersjö-Jess D, Bloch W, Sampson MG, Dollé ME, Puelles VG, Kretzler M, Garinis GA, Huber TB, Schermer B, Benzing T, Schumacher B, Kurschat CE.

Schumacher Laboratory

Meyer Laboratory

PMID:

40392611
Journal:

JCI Insight
Date:

20. Mai 2025

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The stochasticity of biological aging

Meyer DH, Schumacher B

Schumacher Laboratory

Meyer Laboratory

PMID:

40301558
Journal:

Nature Medicine
Date:

29. April 2025

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Invigorating discovery and clinical translation of aging biomarkers

Jacques E, Herzog C, Ying K, Tomusiak A, Kasamoto J, Sehgal R, Paulson S, Reinhard J, Träuble J, Hastings WJ, Tyshkovskiy A, Hägg S, Earls JC, Behrens CE, Lasky-Su J, Zhou G, Morgen E, Tsang JS, Marioni RE, Ma XJ, Stolzing A, Glorioso C, Gootenberg JS, Abudayyeh OO, Argentieri MA, Mak RH, Cox LS, Brack AS, Lauc G, Furman D, Buenrostro JD, Schumacher B, Justice JN, Woods T, Gobel D, Perez VI, Sinclair DA, Maier AB, Barzilai N, Snyder MP, Wyss-Coray T, Horvath S, Ferrucci L, Poganik JR, Moqri M, Gladyshev VN.

Schumacher Laboratory

PMID:

40164770
Journal:

Nat Aging
Date:

31. März 2025

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The novel role of lymphatic vessels in the pathogenesis of ocular diseases

Clahsen T, Hadrian K, Notara M, Schlereth SL, Howaldt A, Prokosch V, Volatier T, Hos D, Schroedl F, Kaser-Eichberger A, Heindl LM, Steven P, Bosch JJ, Steinkasserer A, Rokohl AC, Liu H, Mestanoglu M, Kashkar H, Schumacher B, Kiefer F, Schulte-Merker S, Matthaei M, Hou Y, Fassbender S, Jantsch J, Zhang W, Enders P, Bachmann B, Bock F, Cursiefen C.

Schumacher Laboratory

PMID:

36759312
Journal:

Prog Retin Eye Res
Date:

7. Februar 2025

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Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Lyu YX , Fu Q, Wilczok D, Ying K, … Schumacher B, Zhavoronkov A, Scheibye-Knudsen M, Bakula D

Schumacher Laboratory

PMID:

39418098
Journal:

Aging (Albany NY).
Date:

16. Oktober 2024

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Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY.

Schumacher Laboratory

Meyer Laboratory

PMID:

38900346
Journal:

Geroscience
Date:

20. Juni 2024

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Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging

Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B.

Schumacher Laboratory

PMID:

38894680
Journal:

Nucleic Acids Res
Date:

19. Juni 2024

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DNA repair deficiencies and neurodegeneration

Ropert B, Gallrein C, Schumacher B.

Schumacher Laboratory

PMID:

38640601
Journal:

Elsevier
Date:

1. Juni 2024

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Aging clocks based on accumulating stochastic variation

Meyer DH, Schumacher B

Schumacher Laboratory

Meyer Laboratory

PMID:

38724736
Journal:

Nat Aging
Date:

9. Mai 2024

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Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage

Arvanitaki ES, Goulielmaki E, Gkirtzimanaki K, Niotis G, Tsakani E, Nenedaki E, Rouska I, Kefalogianni M, Xydias D, Kalafatakis I, Psilodimitrakopoulos S, Karagogeos D, Schumacher B, Stratakis E, Garinis GA.

Schumacher Laboratory

PMID:

38635632
Journal:

Proc Natl Acad Sci U S A
Date:

23. April 2024

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Genome instability and DNA repair in somatic and reproductive aging

Panier, S.*, Wang, S.*, Schumacher, B.

Panier Laboratory

Schumacher Laboratory

Wang Laboratory

PMID:

37832947
Journal:

Annu Rev Pathol Mech Dis
Date:

24. Januar 2024

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baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism

Gallrein C, Williams AB, Meyer DH, Messling JE, Garcia A, Schumacher B

Schumacher Laboratory

Meyer Laboratory

PMID:

38100354
Journal:

Cell Rep
Date:

26. Dezember 2023

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Chronic kidney disease promotes ageing in a multiorgan disease network

Benzing T, Schumacher B.

Schumacher Laboratory

PMID:

37237148
Journal:

Nat Rev Nephrol
Date:

26. Mai 2023

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Mitigating age-related somatic mutation burden

Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K.

Schumacher Laboratory

PMID:

37121869
Journal:

Trends Mol Med
Date:

28. April 2023

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The DREAM complex functions as conserved master regulator of somatic DNA repair capacities

Bujarrabal A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi G, Garinis G, Schumacher B.

Schumacher Laboratory

Meyer Laboratory

PMID:

36959262
Journal:

Nat Struct Mol Biol.
Date:

23. März 2023

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Short-Term UVB Irradiation Leads to Persistent DNA Damage in Limbal Epithelial Stem Cells, Partially Reversed by DNA Repairing Enzymes

Volatier T, Schumacher B, Meshko B, Hadrian K, Cursiefen C, Notara M.

Schumacher Laboratory

PMID:

36829542
Journal:

Biology (Basel)
Date:

7. Februar 2023

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Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling

Selle J, Bohl K, Höpker K, Wilke R, Dinger K, Kasper P, Abend B, Schermer B, Müller R, Kurschat C, Nüsken K, Nüsken E, Meyer D, Savai Pullamsetti S, Schumacher B, Dötsch J, Alejandre Alcazar M,

Schumacher Laboratory

Meyer Laboratory

PMID:

36768831
Journal:

Int. J. Mol. Sci
Date:

28. Januar 2023

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Somatic PMK-1/p38 signalling links environmental stress to germ cell apoptosis and heritable euploidy

Soltanmohammadi N*, Wang S*, Schumacher B.

Schumacher Laboratory

Wang Laboratory

PMID:

36650157
Journal:

Nat Commun
Date:

17. Januar 2023

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Inheritance of paternal DNA damage by histone-mediated repair restriction

Wang S, Meyer DH, Schumacher B.

Schumacher Laboratory

Wang Laboratory

Meyer Laboratory

PMID:

36544019
Journal:

Nature
Date:

21. Dezember 2022

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Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells

Uszkoreit S, Meyer DH, Rechavi O, Schumacher B.

Schumacher Laboratory

Journal:

bioRxiv
Date:

22. Juli 2022

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The p53 network: cellular and systemic DNA damage responses in cancer and aging

Vaddavalli PL, Schumacher B.

Schumacher Laboratory

PMID:

35346511
Journal:

Trends Genet
Date:

1. Juni 2022

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Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice

Kasper P, Selle J, Vohlen C, Wilke R, Kuiper-Makris C, Klymenko O, Bae-Gartz I, Schömig C, Quaas A, Schumacher B, Demir M, Bürger M, Lang S, Martin A, Steffen HM, Goeser T, Dötsch J, Alcazar MAA.

Schumacher Laboratory

PMID:

35628414
Journal:

Int J Mol Sci
Date:

17. Mai 2022

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UV Protection in the Cornea: Failure and Rescue

Volatier T, Schumacher B, Cursiefen C, Notara M.

Schumacher Laboratory

PMID:

35205145
Journal:

Biology (Basel)
Date:

10. Februar 2022

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Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity

Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB.

Schumacher Laboratory

PMID:

35136057
Journal:

Nat Commun
Date:

8. Februar 2022

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Meeting Report: Aging Research and Drug Discovery

Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.