Newest Publications

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The stochasticity of biological aging

Meyer DH, Schumacher B
Nature Medicine. 2025 Apr 29
https://doi.org/10.1038/s41591-025-03687-7
Online ahead of print. PMID: 40301558.

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Lyu YX , Fu Q, Wilczok D, Ying K, ... Schumacher B, Zhavoronkov A, Scheibye-Knudsen M, Bakula D
Aging (Albany NY). 2024 Oct 16:16
https://doi.org/10.18632/aging.206135
PMID: 39418098

Invigorating discovery and clinical translation of aging biomarkers

Jacques E, Herzog C, Ying K, Tomusiak A, Kasamoto J, Sehgal R, Paulson S, Reinhard J, Träuble J, Hastings WJ, Tyshkovskiy A, Hägg S, Earls JC, Behrens CE, Lasky-Su J, Zhou G, Morgen E, Tsang JS, Marioni RE, Ma XJ, Stolzing A, Glorioso C, Gootenberg JS, Abudayyeh OO, Argentieri MA, Mak RH, Cox LS, Brack AS, Lauc G, Furman D, Buenrostro JD, Schumacher B, Justice JN, Woods T, Gobel D, Perez VI, Sinclair DA, Maier AB, Barzilai N, Snyder MP, Wyss-Coray T, Horvath S, Ferrucci L, Poganik JR, Moqri M, Gladyshev VN.
Nat Aging. 2025 Apr
https://doi.org/10.1038/s43587-025-00838-w
PMID: 40164770

Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY.
Geroscience. 2024 Jun 20.
https://doi.org/10.1007/s11357-024-01232-x. Online ahead of print.
PMID: 38900346

Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging

Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B.
Nucleic Acids Res. 2024 Jun 19:gkae519.
https://doi.org/10.1093/nar/gkae519. Online ahead of print.
PMID: 38894680

Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence

Siametis A, Stratigi K, Giamaki D, Chatzinikolaou G, Akalestou-Clocher A, Goulielmaki E, Luke B, Schumacher B, Garinis GA.
Nat Commun. 2024 May 14;15(1):4061.
https://doi.org/10.1038/s41467-024-48443-6.

Aging clocks based on accumulating stochastic variation.

Meyer DH, Schumacher B.
Nat Aging. 2024 May 9. doi: 10.1038/s43587-024-00619-x. Online ahead of print.
PMID: 38724736

DNA repair deficiencies and neurodegeneration.

Ropert B, Gallrein C, Schumacher B.
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.
PMID: 38640601

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