Laboratories

Schumacher-Lab

The genome contains all information for building and functionally maintaining the cell. In contrast to any other macromolecule the genome cannot be replaced but instead requires constant repair amid tens of thousands of DNA damaging events that occur daily in a human cell...

Panier Lab

The accurate replication and transmission of genetic material is of fundamental importance for cellular homeostasis and organism viability. Yet, cells are continually exposed to environmental and endogenous genotoxic agents that threaten DNA integrity. Cells respond to DNA damage by engaging highly complex signalling networks that coordinate DNA repair reactions with cell cycle checkpoint activation, chromatin reorganisation, changes in gene expression and metabolic responses...

Pfander Lab

Genome Maintenance Mechanisms in Health and Disease

A stable genome is a fundamental requirement of life. Consistently, all eukaryotes have an elaborate network of genome maintenance mechanisms that ensure stability and involve enzymes that facilitate repair of damaged and broken DNA...

Hoeijmakers Lab

Professor Jan Hoeijmakers’ s group has a longstanding interest in understanding the molecular mechanisms of eukaryotic DNA repair and the clinical consequences of defects in repair pathways...

Wang Lab

DNA damage poses a major threat to genome stability, chromosomal integrity, and cellular function. Defects in transcription-coupled nucleotide excision repair (TC-NER) cause growth and mental retardation, photosensitivity, and premature ageing in Cockayne syndrome (CS) patients...