1990
72. L. Roza, W. Vermeulen, J.B.A. Bergen Henegouwen, A.P.M. Eker, N.G.J. Jaspers, P.H.M. Lohman and J.H.J. Hoeijmakers.
Effects of microinjected photoreactivating enzyme on thymine dimer removal and DNA repair synthesis in normal and xeroderma pigmentosum fibroblasts.
Cancer Research 50: 1905-1910 (1990).
73. G. Weeda, R.C.A. van Ham, R. Mazurel, A. Westerveld, H. Odijk, J. de Wit, D. Bootsma, A.J. van der Eb and J.H.J. Hoeijmakers.
Molecular cloning and biological characterization of the human excision repair gene ERCC-3.
Molec.Cell.Biol. 10: 2570-2581 (1990).
74. G. Gradwohl, J.M. de Murcia, M. Molinete, F. Simonin, M.H.M. Koken, J.H.J. Hoeijmakers and G. de Murcia.
The second Zinc finger domain of poly(ADP-ribose)polymerase targets single strand break specificity.
Proc.Natl.Acad.Sci.USA 87: 2990-2994 (1990).
75. J.H.J. Hoeijmakers.
Cryptic initiation sequence revealed.
Nature 343: 417-418 (1990).
76. R.H. Overmeijer, W. Hart en J.H.J. Hoeijmakers.
De geneeskunde van de toekomst. Het in kaart brengen van het menselijk DNA en de betekenis van het humane genoom project.
Modern Medicine 14: 383-393 (1990).
77. J.H.J. Hoeijmakers, A.P.M. Eker, R.D. Wood and P. Robins.
Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins.
Mutat.Res. 236: 223-238 (1990).
78. P. Reynolds, M.H.M. Koken, J.H.J. Hoeijmakers, S. Prakash and L. Prakash.
The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae.
EMBO J. 9: 1423-1430 (1990).
79. H. Smeets, L. Bachinski, M. Coerwinkel, J. Schepens, J. Hoeijmakers, M. van Duin, K. H. Grzeschik, C.A. Weber, P. de Jong, M.J. Siciliano and B. Wieringa.
A long-range restriction map of the human chromosome 19q13 region: close physical linkage between CKMM and the ERCC-1 and ERCC-2 genes.
Am.J.Hum.Genet. 46: 492-501 (1990).
80. G. Weeda, R.C.A. van Ham, W. Vermeulen, D. Bootsma, A.J. van der Eb and J.H.J. Hoeijmakers.
A presumed DNA helicase, encoded by the excision repair gene ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Cell 62: 777-791 (1990).
81. C. Troelstra, H. Odijk, J. de Wit, A. Westerveld, L.H. Thompson, D. Bootsma and J.H.J. Hoeijmakers.
Molecular cloning of the human excision repair gene ERCC-6.
Molec.Cell.Biol. 10: 5806-5813 (1990).
82. J.H.J. Hoeijmakers and D. Bootsma.
Molecular genetics of eukaryotic DNA excision repair.
Cancer Cells 2: 311-320 (1990).
1991
83. M. Koken, P. Reynolds, D. Bootsma, J. Hoeijmakers, S. Prakash and L. Prakash.
DHR6, a Drosophila homolog of the yeast DNA repair gene RAD6.
Proc.Natl.Acad.Sci.USA 88: 3832-3836 (1991).
84. J.H.J. Hoeijmakers and A.R. Lehmann.
Nucleotide excision repair in different species, SGOMSEC - 8 workshop on Cross-species differences in DNA damage and its consequence.
John Wiley and Sons (1991).
85. G. Weeda, J. Wiegant, M. van der Ploeg, A.H.M. Geurts van Kessel, A.J. van der Eb and J.H.J. Hoeijmakers.
Localization of the xeroderma pigmentosum group B-correcting gene ERCC-3 to human chromosome 2q21.
Genomics 10: 1035-1040 (1991).
86. W. Vermeulen, M. Stefanini, S. Giliani, J.H.J. Hoeijmakers and D. Bootsma.
Xeroderma pigmentosum complementation group H falls into complementation group D.
Mutat.Res. 255: 201-208 (1991).
87. J.H.J. Hoeijmakers.
How relevant is the Escherichia coli Uvr ABC model for excision repair in eukaryotes?
J.Cell Sci. 100: 687-691 (1991).
88. D. Bootsma and J.H.J. Hoeijmakers.
The genetic basis of xeroderma pigmentosum.
Ann.Genet (Paris) 34: 143-150 (1991).
89. G. Weeda, L. Ma, R.C.A. van Ham, D. Bootsma, A.J. van der Eb and J.H.J. Hoeijmakers.
Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's Syndrome.
Carcinogenesis 12: 2361-2368 (1991).
90. G. Weeda, L. Ma, R.C.A. van Ham, A.J. van der Eb and J.H.J. Hoeijmakers.
Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's Syndrome.
Nucl.Acids Res. 19: 6301-6308 (1991).
91. M.H.M. Koken, P. Reynolds, I. Jaspers-Dekker, L. Prakash, S. Prakash, D. Bootsma and J.H.J. Hoeijmakers.
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.
Proc.Natl.Acad.Sci. 88: 8865-8869 (1991).
92. P.B.G.M. Belt, M.F. van Oostenrijk, H. Odijk, J.H.J. Hoeijmakers and C. Backendorf.
Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.
Nucl.Acids Res. 19: 5633-5637 (1991).
93. P.B.G.M. Belt, W. Jongmans, J. de Wit, J.H.J. Hoeijmakers, P. v.d. Putte and C. Backendorf.
Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT-) using an Eppstein-Barr virus derived cDNA expression vector.
Nucl.Acids Res. 19: 4861-4866 (1991).
1992
94. A.R. Lehmann, J.H.J. Hoeijmakers, A.A. van Zeeland, C.M.P. Backendorf, B.A. Bridges, A. Collins, R.P.D. Fuchs, G.P. Margison, R. Montesano, E. Moustacchi, A.T. Natarajan, M. Radman, A. Sarasin, E. Seeberg, C.A. Smith, M. Stefanini, L.H. Thompson, G.P. van der Schans, C.A. Weber, M.Z. Zdzienicka.
Workshop on DNA repair.
Mutat. Res. 273: 1-28 (1992).
95. L. Ma, G. Weeda, A.G. Jochemsen, D. Bootsma, J.H.J. Hoeijmakers and A.J. van der Eb.
Molecular and functional analysis of the XPBC/ERCC-3 promoter: Transcription activity is dependent on the integrity of an Sp1 binding element.
Nucl.Acids Res. 20: 217-224 (1992).
96. M.H.M. Koken, E.M.E. Smit, I. Jaspers-Dekker, B.A. Oostra, A. Hagemeijer, D. Bootsma and J.H.J. Hoeijmakers.
Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosome Xq24-25 and 5q23-31.
Genomics 12: 447-453 (1992).
97. C. Troelstra, R.M. Landsvater, J. Wiegant, M. van der Ploeg, G. Viel, C.H.C.M. Buys and J.H.J. Hoeijmakers.
Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-21.
Genomics 12: 745-749 (1992).
98. A.P.M. Eker, W. Vermeulen, N. Miura, K. Tanaka, N.G.J. Jaspers, J.H.J. Hoeijmakers and D. Bootsma.
Xeroderma pigmentosum group A correcting protein from Calf Thymus.
Mutat.Res. 274: 211-224 (1992).
99. J.H.J. Hoeijmakers and D. Bootsma.
DNA repair: two pieces of the puzzle.
Nature Genetics 1: 313-314 (1992).
100. E. Park, S.N. Guzder, M.H.M. Koken, I. Jaspers-Dekker, G. Weeda, J.H.J. Hoeijmakers, S. Prakash and L. Prakash.
RAD25(SSL2), a yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability.
Proc.Natl.Acad.Sci.USA 89: 11416-11420 (1992).
101. C. Troelstra, A. van Gool, J. de Wit, W. Vermeulen, D. Bootsma and J.H.J. Hoeijmakers.
ERCC6, a member of a subfamily of putative helicases is involved in Cockayne's syndrome and preferential repair of active genes.
Cell 71: 939-953 (1992).
102. M.H.M. Koken, C. Vreeken, S.A.M. Mol, N.C. Cheng, I. Jaspers-Dekker, J.H.J. Hoeijmakers, J.C.J. Eeken, G. Weeda and A. Pastink.
Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation group B correcting gene, ERCC3.
Nucl.Acids Res. 20: 5541-5548 (1992).
1993
103. J.H.J. Hoeijmakers, C. Troelstra and G. Weeda.
DNA repair genes and syndromes from man to yeast.
Alfred Benzon Symposium vol. 35. V.A. Bohr, K. Wassermann, K.H. Kraemer and J.H. Thaysen, eds. Munksgaard, Copenhagen pp 27-41, (1993).
104. G. Weeda, J.H.J. Hoeijmakers and D. Bootsma.
Genes controlling nucleotide excision repair in eukaryotic cells.
BioEssays 15: 394-403 (1993).
105. M.H.M. Koken, J.H. Odijk, M. van Duin, M. Fornerod and D. Bootsma.
Augmentation of protein production by a combination of the T7 RNA polymerase system and ubiquitin fusion.
-Overproduction of the human DNA repair protein, ERCC1, as a ubiquitin fusion protein in Escherichia coli.
Biochem. Biophys. Res. Comm. 195: 643-653, (1993).
106. J.H.J. Hoeijmakers.
Nucleotide excision repair I: from E.coli to yeast.
TIG 9: 173-177, (1993).
107. J.H.J. Hoeijmakers.
Nucleotide excision repair II; from yeast to mammals.
TIG 9: 211-217 (1993).
108. W. Vermeulen, J. Jaeken, N.G.J. Jaspers, D. Bootsma and J.H.J. Hoeijmakers.
Xeroderma pigmentosum complementation group G associated with Cockayne's syndrome.
Am.J.Hum.Genet. 53: 185-193 (1993).
109. M. Stefanini, W. Vermeulen, G. Weeda, S. Giliani, T. Nardo, M. Mezzina, A. Sarasin, J.I. Harper, J.H.J. Hoeijmakers and A.R. Lehmann.
A new nucleotide excision repair gene associated with the genetic disorder trichothiodystrophy.
Am. J. Hum. Genet. 53: 817-821 (1993).
110. M. Molinete, W. Vermeulen, A. Bürkle, J. Ménissier-de Murcia, J.H. Küpper, J.H.J. Hoeijmakers and G. de Murcia.
Overproduction of the poly(ADP-ribose)polymerase DNA binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
EMBO J. 12: 2109-2117 (1993).
111. C. Troelstra, W. Hesen, D. Bootsma and J.H.J. Hoeijmakers.
Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B.
Nucl. Acids Res. 21: 419-426 (1993).
112. G. Weeda and J.H.J. Hoeijmakers.
Genetic analysis of nucleotide excision repair in mammalian cells.
Seminars in Cancer Biol. 4: 105-117 (1993).
113. J.H.J. Hoeijmakers, G. Weeda, C. Troelstra, M.H.M. Koken, P.J. van der Spek and D. Bootsma.
Molecular analysis of human DNA repair genes and syndromes.
Int.J.Cancer 53: 162-163 (1993).
114. L. Schaeffer, R. Roy, S. Humbert, V. Moncollin, W. Vermeulen, J.H.J. Hoeijmakers, P. Chambon and J-M. Egly.
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor. (research article)
Science 260: 58-63 (1993).
115. A.J. van Vuuren, E. Appeldoorn, H. Odijk, A. Yasui, N.G.J. Jaspers, D. Bootsma and J.H.J. Hoeijmakers.
Evidence for a repair enzyme complex involving ERCC1, and the correcting activities of ERCC4, ERCC11 and the xeroderma pigmentosum group F.
EMBO J. 12: 3693-3701 (1993).
116. D. Bootsma and J.H.J. Hoeijmakers.
DNA repair engagement with transcription (News and Views).
Nature 363: 114-115 (1993).
117. J.H.J. Hoeijmakers.
Reparatie van Erfelijke Informatie.
Introductie in de Klinische en Experimentele Oncologie.
Syllabus NVVO p 11-19 (1993).
1994
118. W. Vermeulen, R.J. Scott, S. Potger, H.J. Müller, J, Cole, C.F. Arlett, W.J. Kleijer, D. Bootsma, J.H.J. Hoeijmakers and G. Weeda.
Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.
Am. J. Hum. Genet. 54: 191-200 (1994).
119. M. Mezzina, E. Eveno, O. Chevallier-Lagente, A. Benoit, M. Carreau, W. Vermeulen, J.H.J. Hoeijmakers, M. Stefanini, A.R. Lehmann, C. A. Weber and A. Sarasin.
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells.
Carcinogenesis 15: 1493-1498 (1994).
120. A.J. van Vuuren, W. Vermeulen, L. Ma, G. Weeda, E. Appeldoorn, N.G.J. Jaspers, A.J. van der Eb, J.H.J. Hoeijmakers, and S. Humbert, L. Schaeffer and J-M. Egly.
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2/TFIIH.
EMBO J. 13: 1645-1653 (1994).
121. L. Schaeffer, V. Moncollin, R. Roy, A. Staub., M. Mezzina., A. Sarasin, G. Weeda, J.H.J. Hoeijmakers and J-M. Egly.
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
EMBO J. 13: 2388-2392 (1994).
122. D. Busch, C. Greiner, K. Lewis Rosenfeld, R. Ford, J. de Wit, J.H.J. Hoeijmakers and L.H. Thompson.
Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large scale screening (FAECB).
Mutagenesis 9: 301-306 (1994).
123. L-B. Ma, A. Westbroek, A.G. Jochemsen, G. Weeda, A. Bosch, D. Bootsma, J.H.J. Hoeijmakers and A.J. van der Eb.
Mutational analyis of ERCC3, involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.
Molec. Cell. Biol. 14: 4126-4134 (1994).
124. C. Masutani, K. Sugasawa, J. Yanagisawa, T. Sonoyama, M. Ui, T. Enomoto, K. Takio, K. Tanaka, P.J. van der Spek, D. Bootsma, J.H.J. Hoeijmakers and F. Hanaoka.
Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homolog of yeast RAD23.
EMBO. J. 13: 1831-1843 (1994).
125. D. Bootsma, and J.H.J. Hoeijmakers.
The molecular basis of nucleotide excision repair syndromes.
Mutation Res. 307: 15-23 (1994).
126. S. Keeney, A.P.M. Eker, T. Brody, W. Vermeulen, D. Bootsma, J.H.J. Hoeijmakers and S. Linn.
Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage binding protein.
Proc. Natl. Acad. Sci. USA 91: 4053-4056 (1994).
127. S. Humbert, H. van Vuuren, Y. Lutz, J.H.J. Hoeijmakers, J-M. Egly, and V. Moncollin.
Characterization of p44/SSL1 and p34 subunits of the BTF2/TFIIH transcription/repair factor.
EMBO J. 13: 2393-2398 (1994).
128. G.C. Grosveld, P. Devilee en J.H.J. Hoeijmakers.
De genetica van kanker. in: 'Medische Genetica' (J. Pronk, F.A. Beemer, J.P.M. Geraedts, N.J. Leschot en M.F. Niermeijer eds.) Wetenschappelijke Uitgeverij Bunge, Utrecht, 1994, pp. 242-280.
129. P.J. Van der Spek, E.M.E. Smit, H.B. Beverloo, K. Sugasawa, C. Matsutani, F. Hanaoka, J.H.J. Hoeijmakers and A. Hagemeier.
Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23.
Genomics 23: 651-658 (1994).
130. J.H.J. Hoeijmakers and A.R. Lehmann.
Nucleotide excision repair among species, in: 'Methods to assess DNA damage and repair: Interspecies comparisons' (R.G. Tardiff, P.H.M. Lohman, and G.N. Wogan eds.) John Wiley & Sons, Ltd., Sussex. pp 57-82 (1994).
131. A.J. van Gool, R. Verhage, S.M.A. Swagemakers, P. van der Putte, J. Brouwer, C. Troelstra, D. Bootsma, and J.H.J. Hoeijmakers.
RAD26, the functional S.cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
EMBO J. 13: 5361-5369 (1994).
132. D.F.R. Muris, O. Bezzubova, J-M. Buerstedde, K. Vreeken, A.S. Balajee, C.J. Osgood, C. Troelstra, J.H.J. Hoeijmakers, K. Ostermann, H. Schmidt, A.T. Natarajan, J.C.J. Eeken, P.H.M. Lohmann, and A. Pastink.
Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination.
Mutat. Res. 315: 295-305 (1994).
133. J.H.J. Hoeijmakers.
Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.
Eur. J. Cancer 30A: 1912-1924 (1994).
134. J.H.J. Hoeijmakers and D. Bootsma.
DNA repair: Incisions for excision.
Nature 371: 654-655 (1994).
135. R. Roy, J.P. Adamczewski, T. Seroz, W. Vermeulen, J-P. Tassan, L. Schaeffer, E.A. Nigg, J.H.J. Hoeijmakers and J-M. Egly.
The Mo15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor.
Cell 79: 1093-1101 (1994).
136. J.H.J. Hoeijmakers.
Reparatie van erfelijke informatie en het ontstaan van kanker.
Introductie in de klinische en experimentele oncologie, pp 11-27, 1994.
137. W. Vermeulen, A.J. van Vuuren, E. Appeldoorn, G. Weeda, N.G.J. Jaspers, A. Priestly, C.F. Arlett, A.R. Lehmann, M. Stefanini, M. Mezzina, A. Sarasin, D. Bootsma, J-M. Egly and J.H.J. Hoeijmakers.
Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH). Evidence for the existence of transcription syndromes.
Cold Spring Harbor Symp. Quant. Biol. 59: 317-329, (1994).
1995
138. J.H.J. Hoeijmakers.
Nucleotide excision repair: molecular and clinical implications.
in: 'DNA repair mechanisms: Impact on Human diseases and Cancer', Series 'Molecular Biology Intelligence Unit' (J-M, H Vos, ed), R.G. Landes Company, Biomedical Publishers, pp 125-150, (1995).
139. B.C. Broughton, A.F. Thompson, S.A. Harcourt, W. Vermeulen, J.H.J. Hoeijmakers, E. Botta, M. Stefanini, M. King, C. Weber, J. Cole, C.F. Arlett, A.R. Lehmann.
Molecular and cellular analysis of the DNA repair defect in a patient with xeroderma pigmentosum complementation group D with the clinical features of xeroderma pigmentosum and Cockayne syndrome.
Am. J. Hum. Genet. 56: 167-174 (1995).
140. X.W. Wang, H. Yeh, L. Schaeffer, R. Roy, V. Moncollin, J-M. Egly, Z. Wang, E.C. Friedberg, M.K. Evans, B.G. Taffe, V.A. Bohr, G. Weeda, J.H.J. Hoeijmakers, K. Forrester and C.C. Harris.
p53 modulation of TFIIH-associated nucleotide excision repair activity.
Nature Genetics 10: 188-194 (1995).
141. P.J.M. Hendriksen, J.S. Hoogerbrugge, A.P.N. Themmen, M.H.M. Koken, J.H.J. Hoeijmakers, B.A. Oostra, T. van der Lende and J.A. Grootegoed.
Post-meiotic expression of X- and Y-specific genes during spermatogenesis in mouse.
Developmental Biology 170: 730-733 (1995).
142. D. Bootsma, G. Weeda, W. Vermeulen, H. van Vuuren, C. Troelstra, P. van der Spek and J.H.J. Hoeijmakers.
Nucleotide excision repair syndromes: molecular basis and clinical symptoms.
Phil. Trans. R. Soc. Lond. B 347: 75-81 (1995).
143. Libin Ma, Jan H.J. Hoeijmakers and Alex J. van der Eb.
Mammalian Nucleotide Excision Repair.
Biochim. Biophys. Acta 1242: 137-164 (1995).
144. A.J. van Vuuren, E. Appeldoorn, H. Odijk, S. Humbert, A.P.M. Eker, N.G.J. Jaspers, V. Moncollin, J.-M. Egly and J.H.J Hoeijmakers.
Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities.
Mutat Res. 337: 25-39 (1995).
145. E. Eveno, F. Bourre, X. Quilliet, O. Chevallier-Lagente, L. Roza, A.P.M. Eker, W.J. Kleijer, O. Nikaido, M. Stefanini, J.H.J. Hoeijmakers, D. Bootsma, J.E. Cleaver, A. Sarasin and M. Mezzina.
Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases.
Cancer Res. 55: 4325-4332, (1995).
146. N.G.J. Jaspers and J.H.J. Hoeijmakers.
Nucleotide excision repair in the test tube.
Current Biology 5: 700-702, (1995).
147. A. Nagai, M. Saijo, I. Kuraoka, T. Matsuda, N. Kodo, Y. Nakatsu, T. Mimaki, M. Mino, M. Biggerstaff, R.D. Wood, A. Sijbers, J.H.J. Hoeijmakers and K. Tanaka.
Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein.
Biochem. Biophys. Res. Comm. 211: 960-966, (1995).
148. J.H.J. Hoeijmakers.
Moleculaire analyse van DNA-reparatie en reparatiesyndromen.
Ned. Tijdschr. Geneeskd. 139: 1262 (1995).
149. P.C. Levendag, J.J. Battermann, H. Meertens en J.H.J. Hoeijmakers.
Honderd jaar radiologie in Nederland. V. Radiotherapie, toekomstige ontwikkelingen.
Nederl. Tijdschr. Geneeskd. 139: 2416-2421 (1995).
150. D. Bootsma, J.H.J. Hoeijmakers and N.G.J. Jaspers.
DNA reparatie: het onderhoud van onze genen.
Nederl. Tandartsenblad 50: 810-812 (1995).
151. M. Carreau, E. Eveno, X. Quilliet, O. Chevalier-Lagente, A. Benoit, B. Tanganelli, M. Stefanini, W. Vermeulen, J.H.J. Hoeijmakers, A. Sarasin and M. Mezzina.
Development of a new easy complementation assay for DNA repair-deficient human syndromes using cloned repair genes.
Carcinogenesis 16: 1003-1009 (1995).
152. D. Bootsma and J.H.J. Hoeijmakers.
DNA repair: from the clinical to the molecular level and back.
Louis Jeantet Award Lecture.
Les Cahiers de la Fondation 1995, 10, 16-29 (1996).
1996
153. M.H.M. Koken, J.W. Hoogerbrugge, I. Jaspers-Dekker, J. de Wit, R. Willemsen, H.P. Roest, J.A. Grootegoed and J.H.J. Hoeijmakers.
Expression of the human ubiquitin-conjugating DNA repair enzymes, HHR6A and B suggests a role in spermatogenesis and chromatin modification.
Developm. Biol. 173: 119-132 (1996).
154. X.W. Wang, W. Vermeulen, J.D. Coursen, M. Gibson, S.E. Lupold, K. Forrester, G.Xu, L. Elmore, H. Yeh, J.H.J. Hoeijmakers and C.C. Harris.
p53 induced apoptosis mediated by the XPB and XPD DNA helicases.
Genes & Dev. 10, 1219-1232 (1996).
155. R.A. Verhage, A.J. van Gool, N. de Groot, J.H.J. Hoeijmakers, P. van de Putte and J. Brouwer.
Double mutants in global genome and transcription-coupled repair in S.cerevisiae.
Mol. Cell. Biol. 16: 496-502 (1996).
156. X.W. Wang, M.K. Gibson, W. Vermeulen, H. Yeh, K. Forrester, H.-W. Stürzbecher, J.H.J. Hoeijmakers and C.C. Harris.
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene.
Cancer Res. 55: 6012-6016 (1996).
157. P.J. van der Spek, C.E. Visser, F. Hanaoka, B. Smit, A. Hagemeijer, D. Bootsma and J.H.J. Hoeijmakers.
Cloning, comparative mapping and RNA expression of the mouse homologues of the S.cerevisiae nucleotide excision repair gene RAD23.
Genomics 31: 20-27 (1996).
158. J.R. Hwang, V. Moncollin, W. Vermeulen, T. Seroz, H. van Vuuren, J.H.J. Hoeijmakers, and J M. Egly.
A 3' to 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
J. Biol. Chem. 271: 15898-15904 (1996).
159. W. Vermeulen, D. Bootsma and J.H.J. Hoeijmakers.
Maintaining nature's perfection.
Helix V/1: 23-29 (1996).
160. J.H.J. Hoeijmakers, J-M. Egly and W. Vermeulen.
TFIIH: a key component in multiple DNA transactions.
Curr. Opin. in Genetics and Development 6: 26-33 (1996).
161. K. Sugasawa, C. Masutani, A. Uchida, T. Maekawa, P.J. van der Spek, D. Bootsma, J.H.J. Hoeijmakers and F. Hanaoka.
HHR23B, a human RAD23 homolog, stimulates XPC protein in nucleotide excision repair in vitro.
Molec. Cell. Biol. 16: 4852-4861 (1996).
162. H. Roest, J. van Klaveren, J. de Wit, M.H.M. Koken, J.H. van Roijen, J.T.M. Vreeburg, D. Bootsma, J.A. Grootegoed and J.H.J. Hoeijmakers.
Postreplication repair: the role of RAD6 homologous genes in the mouse.
in U. Hagen, D. Hagen, H. Jung, and C. Streffer, (eds).
Radiation Research, Vol 2 Congress Lectures 439-442 (1996).
163. H. Roest, J. van Klaveren, J. de Wit, C.G. van Gurp, M.H.M. Koken, M. Vermey, J.H. van Roijen, J.T.M. Vreeburg, W.M. Baarends, D. Bootsma, J.A. Grootegoed and J.H.J. Hoeijmakers.
Inactivation of a ubiquitin-conjugating DNA repair enzyme in mice causes a defect in spermatogenesis associated with chromatin modification.
Cell 86: 799-810 (1996).
164. R. Kanaar, C. Troelstra, S.M.A. Swagemakers, J. Essers, B. Smit, J-H. Franssen, A. Pastink, O.Y. Bezzubova, J-M. Buerstedde, B. Clever, W-D. Heyer and J.H.J. Hoeijmakers.
Human and mouse homologs of the Saccharomyces cerevisiae double-strand RAD54 DNA break repair gene: evidence for functional conservation.
Current Biology 6: 828-838 (1996).
165. D. Bootsma and J.H.J. Hoeijmakers.
The DNA repair bible.
Trends in Genetics 12: 79 (1996).
166. A.M. Sijbers, P.J. van der Spek, H. Odijk, J. van den Berg, M. van Duin, A. Westerveld, N.G.J. Jaspers, D. Bootsma and J.H.J. Hoeijmakers.
Mutational analysis of the human nucleotide excision repair gene ERCC1.
Nucl. Acids Res. 24: 3370-3381 (1996).
167. M.J. McKay, C. Troelstra, P.J. van der Spek, R. Kanaar, B. Smit, A. Hagemeijer, D. Bootsma and J.H.J. Hoeijmakers.
Sequence conservation of the Schizosaccharomyces pombe double strand break DNA repair gene rad21.
Genomics 36, 305-315 (1996).
168. P.J. van der Spek, A.P.M. Eker, S. Rademakers, C. Visser, K. Sugasawa, C. Masutani, F. Hanaoka, D. Bootsma, and J.H.J. Hoeijmakers.
XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.
Nucl. Acids Res. 24: 2551-2559 (1996).
169. S-I. Moriwaki, M. Stefanini, A.R.L. Lehmann, J.H.J. Hoeijmakers, J.H. Robbins, I. Rapin, E. Botta, B. Tanganelli, W. Vermeulen, B.C. Broughton and K.H. Kraemer.
DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and Cockayne syndrome resemble xeroderma pigmentosum cells.
J. Invest. Dermatol., 107, 647-653 (1996).
170. A.M. Sijbers, W.L. de Laat, R.A. Ariza, M. Biggerstaff, Y-F. Wei, J.G. Moggs, K.C. Carter, B.K. Shell, E. Evans, M.C. de Jong, S. Rademakers, J. de Rooij, N.G.J. Jaspers, J.H.J. Hoeijmakers and R. Wood.
Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.
Cell 86: 811-822 (1996).
171. N.G.J. Jaspers, G.T.J. van der Horst, W. Vermeulen, E. Appeldoorn, A. Raams, and J.H.J. Hoeijmakers.
Additional involvements of nucleotide excision repair enzymes: key to under¬standing the symptoms of inherited repair deficiency?
in: H.J. Müller, R.J Scott, W. Weber, (eds). Hereditary Cancer, Karger, Basel, pp 129-135 (1996).
1997
172. J.C. Marinoni, R. Roy, W. Vermeulen, P. Miniou, Y. Lutz, G. Weeda, T. Seroz, E.D.M Gomez, J.H.J. Hoeijmakers and J-M. Egly.
Cloning and characterization of p52, the fifth subunit of the core of transcription/repair factor TFIIH.
EMBO J. 16: 1093-1102 (1997).
173. G. Weeda, E. Eveno, I. Donker, W. Vermeulen, O. Chevallier-Lagente, A. Taieb, A. Stary, J.H.J. Hoeijmakers, M. Mezzina and A. Sarasin.
A new complementation group of trichothiodystrophy caused by mutations in the DNA repair/transcription gene XPB/ERCC3.
Am. J. Hum. Genet. 60: 320-329 (1997).
174. D.B. Busch, A.J. van Vuuren, J. de Wit, A. Collins, M. Zdzienicka, D.L. Mitchell, K.W. Brookman, M. Stefanini, R. Riboni, L.H. Thompson, R.B. Albert, A. van Gool and J.H.J. Hoeijmakers.
Phenotypic heterogeneity in FACEB nucleotide excision repair mutants of rodent complementation group 1 and 4.
Mutat. Res. 383: 91-106 (1997).
175. G. Weeda, M. Rossignol, R.A. Fraser, G.S. Winkler, W. Vermeulen, L.J. van 't Veer, L. Ma, J.H.J. Hoeijmakers and J-M. Egly.
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Nucleic Acids Res. 25: 2274-2283 (1997).
176. G.T.J. van der Horst, H. van Steeg, R.J.W. Berg, A.J. van Gool, J. de Wit, G. Weeda, H. Morreau, R.B. Beems, C.F. van Kreijl, F.R. de Gruijl, D. Bootsma and J.H.J. Hoeijmakers.
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 89: 425-435 (1997).
177. G. Weeda, I. Donker, J. de Wit, H. Morreau, R. Janssens, C.J. Vissers, A. Nigg, H. van Steeg, D. Bootsma and J.H.J. Hoeijmakers.
Disruption of mouse ERCC1 results in a novel DNA repair syndrome with growth failure, nuclear abnormalities and senescence.
Current Biology 7: 427-439 (1997).
178. J.H.J. Hoeijmakers, G.T.J. van der Horst, G. Weeda, W. Vermeulen, G.S. Winkler, J. de Boer, W.L. de Laat, A.M. Sijbers, E. Citterio, N.G.J. Jaspers, J-M. Egly, and D. Bootsma.
Recombining DNA damage repair, basal transcription and human syndromes.
In: 'Genomic instability and immortality in cancer' (eds. E. Mihich and L. Hartwell)
Plenum Publishers, New York, pp. 83-96 (1997).
179. J. Essers, R.W. Hendriks, S.M.A. Swagemakers, C. Troelstra, J. de Wit, D. Bootsma, J.H.J. Hoeijmakers and R. Kanaar.
Disruption of mouse RAD54 affects ionizing radiation resistance and homologous recombination.
Cell 89: 195-204 (1997).
180. G.T.J. van der Horst, H. van Steeg, R.J.W. Berg, K. Tanaka, E.C. Friedberg, D. Bootsma and J.H.J. Hoeijmakers.
Transcription-coupled repair as a biodefence mechanism.
in: 'Biodefence Mechanisms against Environmental Stress' (1997).
181. D. Bootsma, K.H. Kraemer, J. Cleaver, and J.H.J. Hoeijmakers.
Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
in: Scriver C.R., Beaudet, A.L., Sly, W.S., Valle, D. (eds). 'The Metabolic Basis of Inherited Disease', Eighth Edition, chapter 159, McGraw-Hill Book Co., New York (1997, CD rom version).
182. A.J. van Gool, E. Citterio, S. Rademakers, R. van Os, W. Vermeulen, A. Constantinou, J M. Egly, D. Bootsma and J.H.J. Hoeijmakers.
The Cockayne syndrome B protein, involved in transcription-coupled repair resides in a RNA polymerase II containing complex.
EMBO J. 16, 5955-5965 (1997).
183. P. Vichi, F. Coin, J-P. Renaud, W. Vermeulen, J.H.J. Hoeijmakers, D. Moras and J-M. Egly.
Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP.
EMBO J. 16, 7444-7456 (1997).
184. W. Vermeulen, J. de Boer, E. Citterio, A.J. van Gool, G.T.J. van der Horst, N.G.J. Jaspers, W.L. de Laat, A.M. Sijbers, P.J. van der Spek, K. Sugasawa, G. Weeda, G.S. Winkler, D. Bootsma, J-M. Egly, and J.H.J. Hoeijmakers.
Mammalian nucleotide excision repair and syndromes.
Bioch. Soc. Transact. 25, 309-315 (1997).
185. C. Masutani, M. Araki, K. Sugasawa, P.J. van der Spek, A. Yamada, A. Uchida, T. Maekawa, D. Bootsma, J.H.J. Hoeijmakers and F. Hanaoka.
Identification and characterization of XPC-binding domain of hHR23B.
Molec. Cell. Biol., 17, 6915-6923 (1997).
186. K. Sugasawa, J.M.Y. Ng, C. Masutani, T. Maekawa, A. Uchida, P.J. van der Spek, A.P.M. Eker, S. Rademakers, C. Visser, A. Aboussekhra, R.D. Wood, F. Hanaoka, D. Bootsma and J.H.J. Hoeijmakers.
Two human homologues of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.
Molec. Cell. Biol., 17, 6925-6931 (1997).
187. R. Kanaar, and J.H.J. Hoeijmakers.
Recombination and Joining; Different means to the same ends.
Genes and Function 1, 165-174 (1997).
188. A.J. van Gool, G.T.J. van der Horst, E. Citterio, and J.H.J. Hoeijmakers.
Cockayne syndrome: defective repair of transcription?
EMBO J. 16: 4155-4162 (1997).
189. B.P. Engelward*, G. Weeda*, M.D. Wyatt, J.L.M. Broekhof, J. de Wit, I. Donker, J.M. Allan, B. Gold, J.H.J. Hoeijmakers and L.D. Samson.
Base excision repair deficient mice lacking the Aag DNA glycosylase.
Proc. Natl. Acad. Sci. USA. 94, 13087-13092 (1997).
*both authors contributed equally
1998
190. D. Bootsma, K.H. Kraemer, J.E. Cleaver and J.H.J. Hoeijmakers.
Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
in: The Genetic Basis of Human Cancer (ed. B. Vogelstein, K.W. Kinzler). (1998, chapter 13, pp. 245-274), McGraw-Hill (New York).
191. H. Xu, I. Swoboda, P.L. Bhalla, A. Sijbers, C. Zhao, E-K. Ong, J.H.J. Hoeijmakers and M.B. Singh.
Plant homolog of the human excision repair gene ERCC1 points to conservation of DNA repair mechanisms.
The Plant Journal 13: 823-829 (1998).
192. J. de Boer, I. Donker, J. de Wit, J.H.J. Hoeijmakers and G. Weeda.
Disruption of the mouse XPD DNA repair/transcription gene results in preimplantation lethality.
Cancer Research 58: 89-94 (1998).
193. G.S. Winkler, W. Vermeulen, F. Coin, J-M. Egly, J.H.J. Hoeijmakers and G. Weeda.
Affinity purification of the human DNA repair/transcription factor TFIIH using (epitope) tagged XPB.
J. Biol. Chem. 273, 1092-1098 (1998).
194. W.L. de Laat, E. Appeldoorn, N.G.J. Jaspers and J.H.J. Hoeijmakers.
DNA structural elements required for ERCC1-XPF endonuclease activity.
J. Biol. Chem. 273, 7835-7842 (1998).
195. G. Weeda, J. de Boer, I. Donker, J. de Wit, S.B. Winkler, G.T.J. van der Horst, W. Vermeulen, D. Bootsma and J.H.J. Hoeijmakers.
Molecular basis of DNA repair mechanisms and syndromes.
Recent Results Cancer Res. 154, 147-155 (1998).
196. R. Kanaar and J.H.J.Hoeijmakers.
From competition to collaboration (News and Views).
Nature 391, 335-338 (1998).
197. E. Citterio, S. Rademakers, G.T.J. van der Horst, A.J. van Gool, J.H.J. Hoeijmakers and W. Vermeulen.
Biochemical and biological characterization of wild-type and ATP-ase-deficient Cockayne syndrome B repair protein.
J. Biol. Chem. 273, 11844-11851 (1998).
198. W.M. Barends, H.P. Roest, J.W. Hoogerbrugge, P.J.M. Hendriksen, J.H.J. Hoeijmakers and J.A. Grootegoed.
Chromatin structure and gene expression during spermatogenesis. In: Testicular function: from gene expression to genetic manipulation (Stefanini, M., Boitani, C., Galdieri, M., Geremia, R., and Palombi, F. eds) Ernst Schering Research Foundation Workshop Supplement 3, Springer Verlag , chapter 5, pp 83 – 103 (1998).
199. K. Sugasawa, J.M.Y. Ng, C. Masutani, P.J. van der Spek, A.P.M. Eker, F. Hanaoka, D. Bootsma and J.H.J. Hoeijmakers.
Xeroderma pigmentosum group C complex is the initiator of global genome repair.
Molecular Cell 2, 223-232 (1998).
200. W.L. de Laat, E. Appeldoorn, K. Sugasawa, N.G.J. Jaspers and J.H.J. Hoeijmakers.
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair.
Genes and Development 12, 2598-2609 (1998).
201. J. de Boer, J. de Wit, H. van Steeg, R.J.W. Berg, H. Morreau, P. Visser, A.R.L. Lehmann, M. Duran, J.H.J. Hoeijmakers and G. Weeda.
A mouse model for the basal transcription/DNA repair disorder trichothiodystrophy.
Molecular Cell 1, 981-990 (1998) (see also minireview Cell 93, 1099-1102, (1998).
202. H.A.R. Bluyssen, R.I. van Os, N.C. Naus, I. Jaspers, J.H.J. Hoeijmakers and A. de Klein.
A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene.
Genomics 54, 331-337 (1998).
203. W.L. de Laat, A.M. Sijbers, H. Odijk, E. Appeldoorn, N.G.J. Jaspers and J.H.J. Hoeijmakers.
Mapping of the interaction domains between human repair proteins ERCC1 and XPF.
Nucleic Acids Res. 26, 4146-4152 (1998).
204. J.H.J. Hoeijmakers.
DNA reparatie en het belang van het gist genoom project voor onderzoek naar het ontstaan van kanker.
Thema nummer KNAW symposium 'Genen in kaart. Mensen in of uit problemen'
(pp 32-40) (1998).
205. J.A. Grootegoed, W.M. Baarends, H.P. Roest and J.H.J. Hoeijmakers.
Knockout mouse model and gametogenic failure.
Molec. and Cellul. Endocrinology 145, 161-166 (1998).
206. J.H.J. Hoeijmakers, G. Weeda, G.T.J. van der Horst, J. de Boer, K. Sugasawa, W. Vermeulen, G.S. Winkler, E. Citterio, A.J. van Gool, W.L. de Laat, A.M. Sijbers, N.G.J. Jaspers, J-M. Egly, and D. Bootsma.
DNA repair, cancer and aging.
South West Cancer News 2, 7-9 (1998).
207. S.M.A. Swagemakers, J. Essers, J. de Wit, J.H.J. Hoeijmakers and R. Kanaar.
The human Rad54 recombination DNA repair protein is a double-stranded DNA-dependent ATP-ase.
J. Biol. Chem. 273, 28292-28297 (1998).
208. R. Kanaar, J.H.J. Hoeijmakers and D.C. van Gent.
Molecular mechanism of double strand break repair.
Trends in Cell Biology 8, 483-489 (1998).
209. G.S. Winkler and J.H.J. Hoeijmakers.
From a DNA helicase to brittle hair.
Nature Genetics 20, 106-107 (1998).
1999
210. S. Parisi, M.J. McKay, M. Molnar, M.A. Thompson, P.J. van der Spek, E. van Drunen-
Schoenmaker, R. Kanaar, E. Lehmann, J.H.J. Hoeijmakers, and J. Kohli.
Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fision yeast to humans.
Mol. Cell. Biol. 19, 3515-3528 (1999) .
211. H.A.R. Bluyssen, N.C. Naus, R.I. van Os, I. Jaspers, J.H.J. Hoeijmakers and A. de Klein.
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Genomics 55, 219-228 (1999).
212. W.M. Baarends, J.W. Hoogerbrugge, H.P. Roest, M. Ooms, J. Vreeburg, J.H.J. Hoeijmakers and J.A. Grootegoed.
Histone ubiquitination and chromatin remodeling in mouse spermatogenesis.
Developmental Biology 207, 322-333 (1999).
213. J. Essers, J.H.J. Hoeijmakers and R. Kanaar.
Pathways of double-strand break repair.
In: 'Diagnosis and treatment of radiation injury'
EC commission, Directorate-General XII, Science Research and Development (1999).
214. T.L.R. Tan, J. Essers, E. Citterio, S.M.A. Swagemakers, J. de Wit, F.E. Benson, J.H.J. Hoeijmakers and R. Kanaar.
The mouse Rad54 recombinational DNA repair protein alters DNA structure and is required for formation of DNA damage-induced Rad51 foci.
Current Biology 9, 325-328 (1999).
215. J. de Boer and J.H.J. Hoeijmakers.
Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair.
Biochimie 81, 127-137 (1999)
216. H. Hiyama, M. Yokoi, C. Masutani, K. Sugasawa, T. Maekawa, K. Tanaka, J.H.J. Hoeijmakers and F. Hanaoka.
Interaction of hHR23 with S5a: the ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26S proteasome.
J. Biol. Chem. 274, 28019-28025 (1999).
217. J. de Boer, H. van Steeg, R.J.W. Berg, J. Garssen, J. de Wit, C.T.M. van Oostrom, R.B. Beems, G.T.J. van der Horst, C.F. van Kreijl, F.R. de Gruijl, D. Bootsma, J.H.J. Hoeijmakers and G. Weeda.
Mouse model for the DNA repair/basal transcription disorder Trichothiodystrophy reveals cancer predisposition.
Cancer Research 59, 3489-3494 (1999).
218. J.H.J. Hoeijmakers.
DNA reparatie en genetische degeneratie.
Spinoza 98, Uitgave NWO. P. 37-54(1999).
219. G.T.J. van der Horst, M. Muijtjens, K. Kobayashi, R. Takano, S-I. Kanno, M. Takao, J. de Wit, A. Verkerk, A.P.M. Eker, D. van Leenen, R. Buijs, D. Bootsma, J.H.J. Hoeijmakers, A. Yasui.
Mammalian blue-light receptor homologs CRY1 and CRY2 are essential for maintenance of the biological clock.
Nature 398, 627-630 (1999) (see also 'News and Views' Nature 398, 557-558, 1999 and Science 284, 422-423, 1999).
220. A.B. Houtsmuller, S. Rademakers, A.L. Nigg, D. Hoogstraten, J.H.J. Hoeijmakers and W. Vermeulen.
Action of DNA repair endonuclease ERCC1/XPF in living cells.
Science 284, 958-961 (1999).
221. W.L. de Laat, N.G.J. Jaspers and J.H.J. Hoeijmakers.
Molecular mechanism of nucleotide excision repair.
Genes & Dev. 13, 768-785 (1999).
222. B.J. Glassner*, G. Weeda*, J.M. Allan, J.L.M. Broekhof, N.H.E. Carls, I. Donker, B.P. Engelward, R.J. Hampson, R. Hersmus, M.J. Hickman, R.B. Roth, H.B. Warren, M.M Wu, J.H.J. Hoeijmakers and L.D. Samson.
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.
Mutagenesis 14, 339-347(1999).
*Both authors equal contribution
223. J. de Boer, G.T.J. van der Horst and J.H.J. Hoeijmakers
Muismutanten als model voor humane verouderingsziekten –verstoorde transcriptie en vroegtijdige veroudering.
Tijdschrift voor Gerontologie en Geriatrie 30, 168-170 (1999).
224. H. Okamura, S. Miyake, Y. Sumi, S. Yamaguchi, A. Yasui, M. Muijtjens, J.H.J. Hoeijmakers, and G.T.J. van der Horst.
Photic induction of mPer1 and mPer2 in Cry-deficient mice lacking a biological clock.
Science, 286, 2531-2534 (1999).
