2000-2009

.

Publications from 2000-2009

2000
225. G.S. Winkler, S.J. Araújo, U. Fiedler, W. Vermeulen, F. Coin, J-M. Egly, J.H.J. Hoeijmakers, R.D. Wood, H.Th.M. Timmers, and G. Weeda.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
J. Biol Chem., 275, 4258-4266 (2000).

226. J. de Boer and J.H.J. Hoeijmakers.
Nucleotide excision repair and human syndromes.
Carcinogenesis (special issue), 21, 453-460 (2000).

227. R. van der Laan, H.P. Roest, J.W. Hoogerbrugge, E.M.E. Smit, R. Slater, W.M. Baarends, J.H.J. Hoeijmakers and J.A. Grootegoed.
Characterization of mRAD18Sc, a mouse homolog of the yeast post-replication repair gene RAD18.
Genomics 69, 86-94 (2000).

228. Y. Nakatsu, H. Asahina, E. Citterio, S. Rademakers, W. Vermeulen, S. Kamiuchi, Y.J. Ping, K.M. Cheh, M. Saijo, N. Kodo, T. Matsuda, J.H.J. Hoeijmakers and K. Tanaka.
XAB2, a novel tetratricopeptide repeat protein, involved in transcription-coupled repair and transcription.
J. Biol. Chem. 275, 34931-34937 (2000).

229. J. Essers, H. van Steeg, J. de Wit, S.M.A. Swagemakers, M. Vermeij, J.H.J. Hoeijmakers, and R. Kanaar.
Homologous and non-homologous recombination differentially affect DNA damage repair in mice.
EMBO J. 19, 1703-1710 (2000).

230. T. Seroz, G.S. Winkler, J. Auriol, R.A. Verhage, W. Vermeulen, B. Smit, J. Brouwer, A.P.M. Eker, G. Weeda, J.-M. Egly, J.H.J. Hoeijmakers.
A human homolog of the yeast nucleotide excision repair gene MMS19 interacts with transcription repair factor TFIIH through the XPB and XPD helicases.
Nucl. Acids Res. 28, 4506-4513 (2000).

231. M.L.G. Dronkert, H.B. Beverloo, R.D. Johnson, J.H.J. Hoeijmakers, M. Jasin, and R. Kanaar
Mouse Rad54 affects DNA doublestrand break repair and sister chromatid exchange.
Molec. Cell. Biol. 20, 3147-3156 (2000).

232. J. Garssen, H. van Steeg, F. de Gruijl, J. de Boer, G.T.J. van der Horst, H. van Kranen, H. van Loveren, M. van Dijk, A. Fluitman, G. Weeda, and J.H.J. Hoeijmakers.
Transcription-coupled and global genome repair differentially influence Ultraviolet-B induced acute skin effects and systemic immunosuppression.
J. Immunol. 164, 6199-6205 (2000).

233. K. Yagita, S. Yamaguchi, F. Tamanini, G.T.J. van der Horst, J.H.J. Hoeijmakers, A. Yasui, J.J. Loros, J.C. Dunlap, and H. Okamura.
Dimerization and nuclear entry of mPER clock proteins in mammalian cells.
Genes & Dev. 14, 1353-1363 (2000).

234. A. de Klein, M. Muijtjens, R. van Os, Y. Verhoeven, B. Smit, A.M. Carr, A.R. Lehmann, and J.H.J. Hoeijmakers.
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.
Current Biol. 10, 479-482 (2000).

235. M.L.G. Dronkert, J. de Wit, M. Boeve, M.L. Vasconcelos, H. van Steeg, T.L.R. Tan, J.H.J. Hoeijmakers and R. Kanaar.
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Molec. Cell. Biol. 20, 4553-4561 (2000).

236. E. Citterio, W. Vermeulen and J.H.J. Hoeijmakers.
Transcriptional healing.
Cell 101, 447-450 (2000).

237. E. Citterio, V. van den Boom, G. Schnitzler, R. Kanaar, E. Bonte, R.E. Kingston, J.H.J. Hoeijmakers and W. Vermeulen.
ATP-dependent chromatin remodeling and histone binding by the Cockayne syndrome B DNA repair-transcription coupling factor.
Molec. Cell. Biol. 20, 7643-7653 (2000).

238. W. Vermeulen, E. Bergmann, J. Auriol, S. Rademakers, P. Frit, E. Appeldoorn, J.H.J. Hoeijmakers and J-M Egly.
Sublimiting concentrations of TFIIH transcription/repair factor causes TTD-A trichothiodystrophy disorder.
Nature Gen. 26, 307-313 (2000), (research article, see also Nature Gen., News and Views, 26, 256-257 (2000).
2001
239. G.S. Winkler, K. Sugasawa, A.P.M. Eker, W.L. de Laat and J.H.J. Hoeijmakers.
ATP-dependent release of inhibition of DNA repair endonucleases XPG and ERCC1-XPF by TFIIH.
Biochemistry 40, 160-165 (2001).

240. A. Boonstra, A. van den Oudenaren, M. Baert, H. van Steeg, P.J.M. Leenen, G.T.J. van der Horst, J.H.J. Hoeijmakers, H. Savelkoul, and J. Garssen.
Differential UVB-induced modulation of cytokine production in XPA, XPC and CSB DNA repair-deficient mice.
J. Inv. Derm. 117, 141-146 (2001).

241. W. Vermeulen, S. Rademakers, N.G.J. Jaspers, E. Appeldoorn, A. Raams, B. Klein, W. Kleijer, L. Kjærsgård, and J.H.J. Hoeijmakers.
A temperature-sensitive disorder in basal transcription and DNA repair in man.
Nature Gen. 27, 299-303 (2001) (see also Bioassays 'Hot News', 23, 671-673 (2001).

242. J.H.J. Hoeijmakers.
From xeroderma pigmentosum to the biological clock. Contributions of Dirk Bootsma to human genetics.
Mutat. Res. 485, 43-59 (2001).

243. D.C van Gent, J.H.J. Hoeijmakers and R. Kanaar.
Chromosomal stability and the DNA double strand break connection.
Nature Reviews 2, 196-206 (2001).

244. J.H.J. Hoeijmakers.
DNA repair mechanisms.
Maturitas 38, 17-23 (2001).

245. E.E. Verhoeven, C. Wyman, G.F. Moolenaar, J.H.J. Hoeijmakers and N. Goosen.
Architecture of nucleotide excision repair complexes: DNA is wrapped by UvrB before and after damage recognition.
EMBO J. 20, 601-611 (2001).

246. D. Bootsma, K.H. Kraemer, J.E. Cleaver, and J.H.J. Hoeijmakers.
Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
in: Scriver C.R., Beaudet, A.L., Sly, W.S., Valle, D. (eds). The Metabolic and Molecular Bases of Inherited Disease, Eighth Edition, Vol 1, chapter 28, McGraw-Hill Book Co., New York. pp. 677-703 (2001).

247. M. Murai, Y. Enokido, N. Inamura, M. Yoshino, Y. Nakatsu, G.T.J. van der Horst, J.H.J. Hoeijmakers, K. Tanaka, H. Hatanaka.
Early postnatal ataxia and abnormal cerebellar development in mice lacking the xeroderma pigmentosum group A and Cockayne syndrome group B DNA repair proteins.
Proc. Natl Acad. Sci. 98, 13379-13384 (2001).

248. J.H.J. Hoeijmakers.
Genome maintenance mechanisms for preventing cancer.
Nature 411, 366-374 (2001).

249. M. Volker, M.J. Moné, P. Karmakar, W. Schul, W. Vermeulen, J.H.J. Hoeijmakers, R. van Driel, A.A. van Zeeland L.H.F. Mullenders.
Sequential assembly of nucleotide excision repair factors in vivo.
Molecular Cell 8, 213-224 (2001).

250. L.J. Niedernhofer, J. Essers, G. Weeda, B. Beverloo, J. de Wit, M. Muitjens, H. Odijk, J.H.J. Hoeijmakers and R. Kanaar.
The structure-specific endonuclease ERCC1/XPF is required for targeted gene replacement in embryonic stem cells.
EMBO J. 20, 6540-6549 (2001).
2002
251. S. Kamiuchi, M. Saijo, E. Citterio, M. de Jager, J.H.J. Hoeijmakers, and K. Tanaka.
Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair.
Proc Natl Acad Sci 99, 201-206 (2002).

252. D. Bootsma, K.H. Kraemer, J.E. Cleaver, and J.H.J. Hoeijmakers.
Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
in: The Genetic Basis of Human Cancer (ed. B. Vogelstein, K.W. Kinzler). (2002, Section II, pp. 211-238), McGraw-Hill (New York).

253. J.M.Y. Ng, H. Vrieling, K. Sugasawa, M.P. Ooms, J.A. Grootegoed, J.T.M. Vreeburg, P. Visser, R.B. Beems, T.G.M.F. Gorgels, F. Hanaoka, J.H.J. Hoeijmakers and G.T.J. van der Horst.
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
Mol. Cell Biol. 22, 1233-1245 (2002).

254. J. Essers, A.B. Houtsmuller, L.. van Veelen, A.L. Nigg, A.. Pastink, W. Vermeulen, J.H.J. Hoeijmakers and R. Kanaar.
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.
EMBO J. 21, 2030-2037 (2002).

255. K. Yagita, F. Tamanini, M. Yasuda, J.H.J. Hoeijmakers, G.T.J. van der Horst and H. Okamura
Nuclear-cytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
EMBO J. 21, 1301-1314 (2002).

256. J. de Boer, J.O. Andressoo, J. de Wit, J. Huijmans, R.B. Beems, H. van Steeg, G. Weeda, G.T.J. van der Horst, W. van Leeuwen, A.P.N. Themmen, M. Meradji and J.H.J. Hoeijmakers
Premature aging in mice deficient in DNA repair and transcription.
Science (research article), 296, 1276-1279 (2002).
(see also Comments in 'Science' May 17; 296, 1250-1251 (2002), and in 'DNA Repair' 2, 437-439, (2003).

257. N.S. Verkaik, R.E.E. van Lange, D. van Heemst, H.T. Brüggenwirth, J.H.J. Hoeijmakers, M.Z. Zdzienicka and D.C. van Gent.
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
Eur. J. Immunol. 32, 701-709 (2002).

258. W. Schul, J. Jans, Y.M.A. Rijksen, K.H.M. Kleman, A.P.M. Eker, J. de Wit, O. Nikaido, A. Yasui, J.H.J. Hoeijmakers and G.T.J. van der Horst.
Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance inphotolyase transgenic mice.
EMBO J. 21, 4719-4729 (2002).

259. D. Hoogstraten, A.L. Nigg, L.H.F. Mullenders, R. van Driel, J.H.J. Hoeijmakers, W. Vermeulen and A.B. Houtsmuller.
Rapid switching of TFIIH between DNA repair and transcription in living cells.
Molec. Cell. 10, 1163-1174 (2002).

260. M. Takao, S. Kanno, T. Shiromoto, R. Hasegawa, H. Ide, S. Ikeda, A.H. Sarker, S. Seki, J.Z. Xing, X.C. Le, M. Weinfeld, K. Kobayashi, J. Miyazaki, M. Muijtjens, J.H.J. Hoeijmakers, G.T.J. van der Horst, and A. Yasui.
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
EMBO J. 21, 3486-3493 (2002).

261. G.M., Segers-Nolten , C. Wyman, N. Wijgers, W. Vermeulen, A.T. Lenferink, J.H.J. Hoeijmakers, J. Greve, C. Otto.
Scanning confocal fluorescence microscopy for single molecule analysis of nucleotide excision repair complexes.
Nucleic Acids Res. 30, 4720-4727 (2002).

262. J. Essers, R.W. Hendriks, J. Wesoly, C.E. Beerens, B. Smit, J.H.J. Hoeijmakers, C. Wyman, M.L. Dronkert, R. Kanaar.
Analysis of mouse Rad54 expression and its implications for homologous recombination.
DNA Repair 1, 779-793 (2002).

263. N.G. Jaspers, A. Raams, M.J. Kelner, J.M. Ng, Y.M. Yamashita, S. Takeda, T.C. McMorris, J.H.J. Hoeijmakers.
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.
DNA Repair 1, 1027-1038 (2002).

264. G.T. van der Horst, L. Meira, T.G. Gorgels, J. de Wit, S. Velasco-Miguel, J.A. Richardson, Y. Kamp, M.P. Vreeswijk, B. Smit, D. Bootsma, J.H.J. Hoeijmakers, E.C. Friedberg.
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
DNA Repair 1, 143-157 (2002).
2003
265. H. de Waard, J. de Wit, T.G. Gorgels, G. van den Aardweg, J.O. Andressoo, M. Vermeij, H. van Steeg, J.H.J. Hoeijmakers, G.T. van der Horst.
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
DNA Repair 2, 13-25 (2003).

266. P. Hasty, J. Campisi, J.H.J. Hoeijmakers, H. van Steeg, J. Vijg.
Aging and genome maintenance: lessons from the mouse?
Science 299, 1355-1359 (2003). Review.

267. W.M. Baarends, E. Wassenaar, J.W.Hoogerbrugge, G. van Cappellen, H.P. Roest, J. Vreeburg, M. Ooms, J.H.J. Hoeijmakers, J.A. Grootegoed.
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Mol. Cell. Biol. 23, 1151-1162 (2003).

268. A. Janicijevic, K. Sugasawa, Y. Shimizu, F. Hanaoka, N. Wijgers, M. Djurica, J.H.J. Hoeijmakers, C. Wyman C.
DNA bending by the human damage recognition complex XPC-HR23B.
DNA Repair 2, 325-336 (2003).

269. J.R. Mitchell, J.H.J. Hoeijmakers, L.J. Niedernhofer.
Divide and conquer: nucleotide excision repair battles cancer and ageing.
Curr. Opin. Cell Biol. 15, 232-240 (2003).

270. M.Y. Ng, G.T.J. van der Horst, W. Vermeulen, K. Sugasawa, H. Vrieling and J.H.J. Hoeijmakers.
A novel mechanism of regulation of DNA repair: stabilization of XPC by DNA damage and by the ubiquitin domain protein RAD23.
Genes and Development 17, 1630-1645 (2003).

271. S. Rademakers, M. Volker, D. Hoogstraten, A.L. Nigg, M. Moné, A.A. van Zeeland, J.H.J. Hoeijmakers, A.B. Houtsmuller and W. Vermeulen.
Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions.
Molec. Cell. Biol. 23, 5755-5767 (2003).

272. C. Arnaudeau-Begard, F. Brellier, O. Chevallier-Lagente, J. Hoeijmakers, F. Bernerd, A. Sarasin and T. Magnaldo.
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes.
Hum. Gene Ther. 14, 983-996 (2003).

273. W. Kolgen, H. van Steeg, G.T.J. van der Horst, J.H.J. Hoeijmakers, W.A. Vlogen, F.R. de Gruijl and J. Garssen.
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
J. Invest. Dermatol. 121, 751-756 (2003).

274. K.E. Diderich, J.H.J. Hoeijmakers and J.P. van Leeuwen.
Accelerated bone aging in the trichothiodystrophy mouse model.
J Gerontol A Biol Sci Med Sci. 58, 969 (2003).

275. E. Weterings, N.S. Verkaik, H.T. Bruggenwirth, J.H.J. Hoeijmakers and D.C. van Gent.
The role of DNA dependent protein kinase in synapsis of DNA ends.
Nucleic Acids Res. 31, 7238-7246 (2003).

276. X.D. Zhu, L. Niedernhofer, B. Kuster, M. Mann, J.H.J. Hoeijmakers and T. de Lange.
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Molecular Cell 12, 1489-1498 (2003).
2004
277. M. Budzowska, I. Jaspers, J. Essers, H. de Waard, E. van Drunen, K. Hanada, B. Beverloo, R.W. Hendriks, A. de Klein, R. Kanaar, J.H.J. Hoeijmakers and A. Maas.
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.
Embo J. 23, 3548-3558 (2004).

278. V. van den Boom, E. Citterio, D. Hoogstraten, A. Zotter, J-M. Egly, W.A. van Cappellen, J.H.J. Hoeijmakers, A.B. Houtsmuller and W. Vermeulen.
DNA damage stabilizes interaction of CSB with the transcription elongation machinery.
J. of Cell Biology 166, 27-36 (2004).

279. Y.Okuda, R. Nishi, J.M.Y. Ng, W. Vermeulen, G.T. van der Horst, T. Mori, J.H.J. Hoeijmakers, F. Hanaoka and K. Sugasawa.
Relative levels of the two mammalian Rad23 homolgs determine composition and stability of the xeroderma pigmentosum group C protein complex.
DNA repair 3, 1285-1295 (2004).

280. G. Giglia-Mari, F. Coin, J.A. Ranish, D. Hoogstraten, A. Theil, N. Wijgers, N.G.J. Jaspers, A. Raams, M. Argentini, P.J. van der Spek, E. Botta, M. Stefanini, J-M. Egly, R. Aebersold, J.H.J. Hoeijmakers and W. Vermeulen.
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome Trichothiodystrophy group A.
Nature Genet. 36, 714-719 (2004).

281. H.P. Roest, W.M. Baarends, J. de Wit, J.W. van Klaveren, E. Wassenaar, J.W. Hoogerbrugge, W.A. van Cappellen, J.H.J. Hoeijmakers and J.A. Grootegoed.
The ubiquitin-conjugating DNA repair enzyme is a maternal factor essential for early embryonic development in mice.
Molec. Cell Biol. 24, 5485-5495 (2004).

282. M.J. Moné, T. Bernas, C. Dinant, F.A. Goedvree, E.M.M. Manders, M.Volker, A.B. Houtsmuller, J.H.J. Hoeijmakers, W. Vermeulen and R.van Driel.
In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair.
Proc. Natl. Acad. Sci. USA 101, 15933-15937 (2004).

283. L.J. Niedernhofer, H. Odijk, M. Budzowska, E. van Drunen, A. Maas, A.F. Theil, J. de Wit, N.G.J. Jaspers, H.B. Beverloo, J.H.J. Hoeijmakers and R. Kanaar.
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
Molec. Cell Biol. 24, 5776-5787 (2004).

284. C.E. Schrader, J. Vardo, E. Linehan, M.Z. Twarog, L.J. Niedernhofer, J.H. J. Hoeijmakers and J. Stavnezer.
Deletion of the nucleotide excision repair gene ERCC1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.
J. Exp. Med. 200, 321-330 (2004).

285. H. de Waard, J. de Wit, J-O. Andressoo, C.T. van Oostrom, B. Riis, A. Weimann, H.E. Puolsen, H. van Steeg, J.H.J. Hoeijmakers and G.T.J. van der Horst.
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
Molec. Cell Biol. 24, 7941-7948 (2004).

286. R. van der Laan, E.J. Uringa, E. Wassenaar, J.W. Hoogerbrugge, E. Sleddens, H. Odijk, H. Roest, W. de Boer, J.H.J. Hoeijmakers, J.A. Grootegoed and W.M. Barends.
Ubiquitin ligase mRAD18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
J. Cell Sci., 227, 5023-5033 (2004).

287. N. Beerens, J.H.J. Hoeijmakers, R. Kanaar, W. Vermeulen and C. Wyman.
The CSB protein actively wraps DNA.
Journal of Biological Chemistry.
2004: Online November 16; M409147200.
2005
288. J. Essers, W.A. van Capellen, A.F. Theil, E. van Drunen, N.G.J. Jaspers, J.H.J. Hoeijmakers, C. Wyman, W. Vermeulen and R. Kanaar.
Dynamics of relative chromosome position during the cell cycle.
Molecular Biological Cell 2, 769-775 (2005).
2004: On line December 1st.

289. J.M. Prasher, A.S. Lalai, C. Heijmans-Antonissen, R.E. Ploemacher, J.H. Hoeijmakers, I.P. Touw, L.J. Niedernhofer.
Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1(-/-) mice
EMBO J. 4, 861-71 (2005).

289. R. van der Laan, W.M. Baarends, E. Wassenaar, H.P. Roest, J.H. Hoeijmakers and J.A. Grootegoed.
Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.
Int. J. Androl. 1:1-15 (2005).

290. J. Jans, W. Schul, Y.G. Sert, Y. Rijksen, H. Rebel, A.P. Eker, S. Nakajima, H. van Steeg, F.R. de Gruijl, A. Yasui, J.H. Hoeijmakers and G.T. van der Horst.
Powerful skin cancer protection by a CPD-photolyase transgene.
Curr. Biol. 152, 105-15 (2005).

291. W.M. Baarends, E. Wassenaar, R. van der Laan, J. Hoogerbrugge, E. Sleddens-Linkels, J.H. Hoeijmakers, P. de Boer and J.A. Grootegoed.
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.
Mol. Cell Biol. 3, 1041-53 (2005).

292. J.O. Andressoo and J.H. Hoeijmakers.
Transcription-coupled repair and premature ageing.
Mutat. Res. 577, 179-194 (2005).

293. S.W. Wijnhoven, R.B. Beems, M. Roodbergen, J. van den Berg, P.H. Lohman, K. Diderich, G.T. van der Horst, J. Vijg, J.H. Hoeijmakers and H. van Steeg.
Accelerated aging pathology in ad libitum fed Xpd (TTD) mice is accompanied by features suggestive of caloric restriction.
DNA Repair 11, 1314-24 (2005).

294. C. Backendorf, J. de Wit, M. van Oosten, G.J. Stout, J.R. Mitchell, A.M. Borgstein, G.T. van der Horst, F.R. de Gruijl, J. Brouwer, L.H. Mullenders and J.H. Hoeijmakers.
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice.
DNA Repair 11, 1325-36 (2005).

295. G.A. Garinis, J.R. Mitchell, M.J. Moorhouse, K. Hanada, H. de Waard, D. Vandeputte, J. Jans, K. Brand, M. Smid, P.J. van der Spek, J.H. Hoeijmakers, R. Kanaar and G.T. van der Horst. Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.
EMBO J. 22, 3952-62 (2005).

296. K. Tripsianes, G. Folkers, E. Ab, D. Das, H. Odijk, N.G. Jaspers, J.H. Hoeijmakers, R. Kaptein and R. Boelens.
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excison repair.
Structure 12, 1849-58 (2005).

297. L.J. Niedernhofer, A.S.Lalai and J.H. Hoeijmakers.
Fanconi anemia (cross)linked to DNA repair.
Cell 7, 1191-8 (2005).

2006

298. S.A. Martomo, W.W. Yang, A. Vaisman, A. Maas, M. Yokoi, J.H. Hoeijmakers, F. Hanaoka, R. Woodgate and P.J. Gaerhart.
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota
DNA Repair 3, 392-8 (2006).

299. M.E. Dolle, R.A. Busuttil, A.M. Garcia, S. Wijnhoven, E. van Drunen, L.J. Niedernhofer, G.T.J. van der Horst, J.H. Hoeijmakers, H. van Steeg and J. Vijg.
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Mutat. Res. 1-2, (2006).

300. H. Lans and J.H. Hoeijmakers.
Cell Biology: ageing nucleus gets out of shape.
Nature 440, 32-4 (2006).

301. G. Giglia-Mari, C. Miquel, A.F. Theil, P.O. Mari, D. Hoogstraten, J.M. Ng, C. Dinant, J.H. Hoeijmakers and W. Vermeulen.
Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol. 6, 952-963 (2006).

302. S. Bergink, F.A. Salomons, D. Hoogstraten, T.A. Groothuis, H. de Waard, J. Wu, L. Yuan, E. Citterio, A.B. Houtsmuller, J. Neefjes, J.H. Hoeijmakers, W. Vermeulen and N.P. Dantuma.
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A
Genes Dev. 20, 1343-52 (2006).

303. S. Bergink, L.A. Severijnen, N. Wijgers, K. Sugasawa, H. Yousaf, J.M. Kros, J. van Swieten, B.A. Oostra and J.H. Hoeijmakers.
The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodgenerative disorders without hampering DNA repair.
Neurobiology Disorders 3, 708-716 (2006).

304. J.O. Andressoo, J.R. Mitchell, J. de Wit, D. Hoogstraten, M. Volker, W. Toussaint, E. Speksnijder, R.B. Beems, H. van Steeg, J. Jans, C.I. de Zeeuw, N.G. Jaspers, A. Raams, A.R. Lehmann, W. Vermeulen, J.H. Hoeijmakers and G.T. van der Horst.
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer Cell 2, 121-132 (2006).

305. J. Jans, G.A. Garinis, W. Schul, A. van Oudenaren, M. Moorhouse, M. Smid, Y.G. Sert, A. van der Velde, Y. Rijksen, F.R. de Gruijl, P.J. van der Spek, A. Yasui, J.H. Hoeijmakers, P.J. Leenen and G.T. van der Horst.
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Molecular Cell Biology 22, 8515-8526 (2006).

306. A. Zotter, M.S. Luijsterburg, D.O. Warmderdam, S. Ibrahim, A. Nigg, W.A. van Cappellen, J.H. Hoeijmakers, R. van Driel, W. Vermeulen and A.B. Houtsmuller.
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced DNA damage depend on functional TFIIH.
Molecular Cell Biology 23, 8868-8879 (2006).

307. J.O. Andressoo, J. Jans, J. de Wit, F. Coin, D. Hoogstraten, M. van de Ven, W. Toussaint, J. Huijmans, H.B. Thio, W.J. van Leeuwen, J. de Boer, J.M. Egly, J.H. Hoeijmakers, G.T. van der Horst and J.R. Mitchell.
Rescue of progeria in trichothiodystrophy by homozygous lethal lethal Xpd alleles.
PLoS Biology 24, 8868-8879 (2006).

308. L.J. Niedernhofer, G.A. Garinis, A. Raams, S.A. Lalai, A.R. Robinson, E. Appeldoorn, H. Odijk, R. Oostendorp, A. Ahmad, W. van Leeuwen, A. Theil, W. Vermeulen, G.T. van der Horst, P. Meinecke, W. Kleijer, J. Vijg, N.G.J. Jaspers and J.H.J. Hoeijmakers.
A new progeriod syndrome reveals that genotoxic stress suppresses the somatotroph axis
Nature 444, 1038-1043 (2006) (see also accompanying 'News and Views', by Kirkwood).

309. J.O. Andressoo, J.H.J. Hoeijmakers and J.R. Mitchell.
Nucleotide excision repair disorders and the balance between cancer and aging.
Cell Cycle 24, 2886-2888 (2006).

310 M. van de Ven, J.O. Andressoo, V.B. Holcomb, M. von Lindern, W.M. Jong, C.I. de Zeeuw, Y. Suh, P. Hasty, J.H.J. Hoeijmakers, G.T.J. van der Horst and J.R. Mitchell.
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.
PLoS Genet. 2, 192 (2006).

2007

311. M. van de Ven, J.O. Andressoo, V.B. Holcomb, P. Hasty, Y. Suh, H. van Steeg, G.A. Garinis, J.H. Hoeijmakers and J.R. Mitchell.
Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging.
Mech. Ageing Development 2, 58-63 (2007).

312. T.G. Gorgels, I. van der Pluijm, R.M. Brandt, G.A. Garinis, H. van Steeg, G. van den Aardweg, G.H. Jansen, J.M. Ruijter, A.A. Bergen, D. van Norren, J.H.J. Hoeijmakers and G.T.J. van der Horst.
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.
Molecular Cell Biology 4, 1433-1441 (2007).

313. I. van der Pluijm, G.A. Garinis, R.M.C. Brandt, T.G.M.F. Gorgels, S.W. Wijnhoven, K.E.M. Diderich, J. de Wit, J.R. Mitchell, C. van Oostrom, R. Beems, L.J. Niedernhofer, S. Velasco, E.C. Friedberg, K. Tanaka, H. van Steeg, J.H.J. Hoeijmakers, G.T.J. van der Horst.
Impaired genome maintenance suppresses the GH/IGF1 axis in Cockayne syndrome mice. PLoS Biol. 5, 23-38 (2007).

314. A.A. van Apeldoorn, J. de Boer, H. van Steeg, J.H.J. Hoeijmakers, C. Otto and C.A. van Blitterswijk.
Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy.
J. Gerontol. A Biol. Sci. Med. Sci. 1, 34-40 (2007).

315. N.G. Jaspers, A. Raams, M.C. Silengo, N. Wijgers, L.J. Niedernhofer, A.R. Robinson, G. Giglia-Mari, D. Hoogstraten, W.J. Kleijer, J.H.J. Hoeijmakers and W. Vermeulen.
First reported patient with human DNA ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
Am. J. Hum. Genet. 3, 457-466 (2007).

316. D.J. Rossi, D. Bryder, A. Nussenschweig, J.H.J. Hoeijmakers and I.I. Weinberg.
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.
Nature 447 (7145), 725-9 (2007).

317. J.H.J. Hoeijmakers.
Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases.
Mechanisms of Aging Development 128, 460-462 (2007).

2008

318. V.A. Bohr, D.M. Wilson III, N.C. de Souza-Pinto, I. van der Pluijm, J.H.J. Hoeijmakers.
DNA Repair and Aging.
In: Molecular Biology of Aging, Cold Spring Harbor Laboratory Press 309-346 (2007).
319. J.P. Melis, S.W. Wijnhoven, R.B. Beems, M. Roodbergen, J. van den Berg, H. Moon, E. Friedberg, G.T. van der Horst, J.H. Hoeijmakers, J. Vijg, H. van Steeg.
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Cancer Research 1 68 (5), 1347-53 (2008).

320. B. Schumacher, G.A. Garinis, J.H. Hoeijmakers.
Age to survive: DNA damage and aging.
Trends in Genetics 24, 77-85 (2008).

321. D. Das, K. Tripsianes, N.G. Jaspers, J.H. Hoeijmakers, R. Kaptein, R. Boelens, G.E. Folkers.
The HhH domain of the human DNA repair protein XPF forms stable homodimers.
Proteins 70, 1551-63 (2008).

322. A. Ahmad, A.R. Robinson, A. Duensing, E. van Drunen, H.B. Beverloo, D.B. Weisberg, P. Hasty, J.H. Hoeijmakers, L.J. Niedernhofer.
ERCC1-XPF endonuclease facilitates DNA double-strand break repair.
Molecular Cell Biology 16, 5082-5092 (2008).

323. H. de Waard, E. Sonneveld, J. de Wit, R. Esveldt-Van Lange, J.H. Hoeijmakers, H. Vrieling,
G.T. van der Horst.
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
DNA Repair 10, 1659-1669 (2008).

324. D. Hoogstraten, S. Bergink, V.H. Verbiest, M.S. Luijsterburg, B. Geverts, A. Raams, C. Dinant,
J.H. Hoeijmakers, W. Vermeulen, A.B. Houtsmuller.
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.
Journal of Cell Science 121, 2850-2859 (2008).

325. B. Schumacher, I. van der Pluijm, M.J. Moorhouse, T. Kosteas, A.R. Robinson, Y. Suh, T.M. Breit, H. van Steeg, L.J. Niedernhofer, W. van IJcken, A. Bartke, S.R. Spindler, J.H. Hoeijmakers, G.T. van der Horst, G.A. Garinis.
Delayed and accelerated aging share common longevity assurance mechanisms.
PLoS Genetics 15, e1000161 (2008).

326. A. Motegi, H.J. Liaw, K.Y. Lee, H.P. Roest, A. Maas, X. Wu, H. Moinova, S.D. Markowitz, H. Ding, J.H. Hoeijmakers, K. Myung.
Polyubiquitination of profilerating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
PNAS 34, 12114-12116 (2008).

327. S. Alekseev, M.S. Luijsterberg, A. Pines, B. Geverts, P.O. Mari, G. Giglia-Mari, H. Lans, A.B. Houtsmuller, L.H. Mullenders, J.H. Hoeijmakers, W. Vermeulen.
Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Molecular Cell Biology 28, 7402-7413 (2008).

328. G.A. Garinis, G.T. van der Horst, J. Vijg., J.H. Hoeijmakers.
DNA damage and ageing: new-age ideas for an age-old problem.
Nature Cell Biology 10, 1241-1247(2008).

329. B. Schumacher, J.H. Hoeijmakers, G.A. Garinis.
Sealing the gap between nuclear DNA damage and longevity.
Molecular Cell Endocrinology 1, 112-117(2008).

330. J.Y. Park, M-O Cho, S. Leonard, B. Calder, I.S. Mian, W.H. Kim, S. Wijnhoven, H. van Steeg, J. Mitchell, G.T.J. van der Horst, J.H.J. Hoeijmakers, P. Cohen, J. Vijg, Y. Suh.
Homeostatic Imbalance between apoptosis and cell renewal in the liver of premature aging xpd/ttd mice.
PLoS One 3, e2346 (2008).

331. Y. Roche, D. Zhang, G.M.J. Segers-Nolten, W. Vermeulen, C. Wyman, K. Sugasawa, J.H.J. Hoeijmakers, C. Otto.
Fluorescence Correlation Spectroscopy of the binding of nucleotide excision repair protein XPC- hHr23B with DNA substrates.
Journal of Fluorescence 18, 987-995 (2008).

2009

332. A. Inagaki, W.A. van Cappellen, R. van der Laan, A.B. Houtsmuller, J.H. Hoeijmakers, J.A. Grootegoed, W.M. Baarends.
Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.
DNA Repair 2, 190-201 (2009).

333. R. Nishi, S. Alekseev, C. Dinant, D. Hoogstraten, A.B. Houtsmuller, J.H.J.Hoeijmakers, W. Vermeulen, F. Hanaoka, K. Sugasawa.
UV-DDB dependent regulation of nucleotide excision repair kinetics in living cells.
DNA Repair 8, 767-776 (2009).

334. J.O. Andressoo, G. Weeda, J. de Wit, J.R. Mitchell, R.B. Beems, H. van Steeg, G.T. van der Horst, J.H. Hoeijmakers.
An XPB mouse model for combined xeroderma pigmentosum and Cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Molecular Cell Biology 5, 1276-1290 (2009).

335. J. Pothof, N.S. Verkaik, W. van IJcken, E.A. Wiemer, V.T. Ta, G.T. van der Horst, N.G. Jaspers, D.C. van Gent, J.H. Hoeijmakers, S.P. Persengiev.
MicroRNA-mediated gene silencing modulates the UV-induced DNA damage response.
EMBO Journal 14, 2090-2099 (2009).

336. G.A. Garinis, L.M. Uittenboogaard, H. Stachelscheid, M. Fousteri, W. van IJcken, T.M. Breit, H. van Steeg, L.H. Mullenders, G.T. van der Horst, J.c. Brüning, C.M. Niessen, J.H. Hoeijmakers, B. Schumacher.
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
Nat Cell Biol. 11, 604-615 (2009).

337. D. Susa, J.R. Mitchell, M. Verweij, M. van de Ven, H. Roest, S. van den Engel, I. Bajema, K. Mangundap, J.N. IJzermans, J.H. Hoeijmakers, R.W. de Bruin.
Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.
Aging Cell 8, 192-200 (2009).

338. J.H. Hoeijmakers.
DNA Damage, aging, and cancer.
NEJM 361, 1475-1485 (2009).

339. G. Giglia-Mari, A.F. Theil, P-O Mari, S. Mourgues, J. Nonnekens, L.O. Andrieux, J. de Wit, C. Miquel, N. Wijgers, A. Maas, M. Fousteri, J.H. Hoeijmakers, W. Vermeulen.
Differentiation driven changes in the dynamic organization of basal transcription initiation
PLoS Biol, 7, e10000220 (2009).

340. H. Alves, U. Munoz-Najar, J. de Wit, A.J.S. Renard, J.H.J. Hoeijmakers, J.M. Sedivy, C. van Blitterswijk, J. de Boer.
A link between the accumulation of DNA damage and loss of multipotency of human mesenchymal stromal cells.
Journal of Cellular and Molecular Medicine Oct 10, [Epub ahead of print ](2009).

341. T.M. van Ginhoven, J.R. Mitchell, M. Verweij, J.H. Hoeijmakers, J.N. IJzermans, R.W. de Bruin.
The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury.
Liver Transplantation 29, 1183-1191 (2009).

342. D.C. van Gent, J.H. Hoeijmakers.
DNA double strand break repair: zooming in on the focus.
Cell Cycle 23, 3813-3815 (2009).

343. J. Pothof, N.S. Verkaik, J.H. Hoeijmakers, D.C. van Gent.
MicroRNA responses and stress granule formation modulate the DNA damage response.
Cell Cycle 8, 3462-3468 (2009).

344. B. Schumacher, J.H. Hoeijmakers, G.A. Garinis.
Sealing the gap between nuclear DNA damage and longevity.
Molecular Cell Endorinology 1, 112-117 (2009).

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