2010-2019

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Publications from 2010-2019

2010
345. J.R. Mitchell, M. Verweij, K. Brand, M. van de Ven, N. Goemaere, S. van den Engel, T. Chu, F. Forrer, C. Müller, M. de Jong, W. van IJcken, J.N. IJzermans, J.H. Hoeijmakers, R.W. de Bruin.
Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.
Aging Cell 1, 40-53 (2010).

345. A. Ahmad, J.H. Enzlin, N. Bhagwat, N. Wijgers, A. Raams, E. Appeldoorn, A.F. Theil, J.H. Hoeijmakers, W. Vermeulen, N.G.J. Jaspers, O.D. Schärer, L.J. Niedernhofer.
Mislocaliztion of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.
PLoS Genet. 5;6(3):e1000871 (2010).

346. H. Lans, J.A. Marteijn, B. Schumacher, J.H. Hoeijmakers, G. Jansen, W. Vermeulen.
Involvement of global genome repair, transcription coupled repair and chromatin remodeling
in UV DNA damage response changes during development.
PLoS Genet. 2010 May 6;6:e1000941.

347. T.M. van Ginhoven, W.A. Dik, J.R. Mitchell, M.A. Smits-Te Nijenhuis, C. van Holten-Neelen, H. Hooijkaas, J.H. Hoeijmakers, R.W. de Bruin, J.N. Ijzermans.
Dietary restriction modifies certain aspects of the postoperative acute phase response.
J. Surg. Res. 171, 582-589. (2010).

348. M.C. de Waard, I. van der Pluijm, N. Zuiderveen Borgesius, L.H. Comley, E.D. Haasdijk, Y. Rijksen, Ridwan Y, Zondag G, J.H. Hoeijmakers, Y. Elgersma, T.H. Gillingwater, D. Jaarsma.
Age-related motor neuron degeneration in DNA repair-deficient ERCC1 mice.
Acta Neuropathol. 120, 461-475 (2010).

349. V. Vanhooren, S. Dewaele, C. Libert, S. Engelborghs, P.P. De Deyn, O. Toussaint, F. Debacq-Chainiaux, M. Poulain, Y. Glupczynski, C. Franceschi, K. Jaspers, I. van der Pluijm, J.H. Hoeijmakers, C.C. Chen.
Serum N-glycan profile shift during human ageing.
Exp. Gerontol. 45 (10), 738-743 (2010).
2011
351. T.M. van Ginhoven, R.W. de Bruin, M. Timmermans, J.R. Mitchell, J.H. Hoeijmakers, J.N. IJzermans.
Pre-operative dietary restriction is feasible in live-kidney donors.
Clin Transplant 25 (3), 486-494 (2011).

352. S.M. Botter, M. Zar, G.J. van Osch, H. van Steeg, M.E. Dollé, J.H. Hoeijmakers, H. Weinans, J.P. van Leeuwen.
Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.
Age 33 (3), 247-260 (2011).

353. P.H. Krijger, K.Y. Lee, N. Wit, P.C. van den Berg, X. Wu, H.P. Roest, A. Maas, H. Ding, J.H. Hoeijmakers, K. Myung, H. Jacobs.
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
DNA Repair 10 (3), 438-444 (2011).

354. M.D. Wouters, D.C. van Gent, J.H. Hoeijmakers, J. Pothof.
MicroRNAs, the DNA damage response and cancer.
Mutat. Res. 717 (1-2), 54-66 (2011).

355. M. Verweij, T.M. van Ginhoven, J.R. Mitchell, W. Sluiter, S. van den Engel, H.P. Roest, E. Torabi, J.N. IJzermans, J.H. Hoeijmakers, R.W. de Bruin.
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.
Liver Transpl. 17 (6), 695-704 (2011).

356. K. Diderich, M. Alanazi, J.H. Hoeijmakers.
Premature aging and cancer in nucleotide excision repair-disorders.
DNA Repair 10 (7), 772-780 (2011).

357. A. Inagaki, E. Sleddens-Linkels, E. Wassenaar, M. Ooms, W.A. van Cappellen, J.H. Hoeijmakers, J. Seibler, T.F. Vogt, M.K. Shin, J.A. Grootegoed, W.M. Baarends.
Meiotic functions of RAD18.
J. Cell Sci. 124 (Pt 16), 2837-2850 (2011).

358. K.E. Diderich, C. Nicolaije, M. Priemel, J.H. Waarsing, J.S. Day, R.M. Brandt, A.F. Schilling, S.M. Botter, H. Weinans, G.T. van der Horst, J.H. Hoeijmakers, J.P. van Leeuwen.
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
Age Aug 4. [Epub ahead of print] (2011).

359. A. Inagaki, E. Sleddens-Linkels, W.A. van Cappellen, R.G. Hibbert, T.K. Sixma, J.H. Hoeijmakers, J.A. Grootegoed, W.M. Baarends.
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
PLoS One 6 (8) (2011).

360. N.Z. Borgesius, M.C. de Waard, I. van der Pluijm, A. Omrani, G.C. Zondag, G.T. van der Horst, D.W. Melton, J.H. Hoeijmakers, D. Jaarsma, Y.Elgersma.
Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.
J. Neurosci. 31 (35), 12543-12553 (2011) .
(selected by Nature as the Research Highlight in Neurobiology, Nature 477, 252, 2011).

361. M. Verweij, M. van de Ven, J.R. Mitchell, S. van den Engel, J.H. Hoeijmakers, J.N. IJzermans, R.W. de Bruin.
Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice.
Transplantation 92 (7), 752-758 (2011).

362. D. Jaarsma, I. van der Pluijm, M.C. de Waard, E.D. Haasdijk, R. Brandt, M. Vermeij, Y. Rijksen, A. Maas, H. van Steeg, J.H. Hoeijmakers, G.T. van der Horst.
Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.
PLoS Genet. 7 (12) (2011).
2012
363. M. Spoor, A.P. Nagtegaal, Y. Ridwan, N.Z. Borgesius, B. van Alphen, I. van der Pluijm, J.H. Hoeijmakers, M.A. Frens, J.G. Borst.
Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse.
Mech Ageing Dev. 133(2-3):59-67 (2012).

364. M.J. Végh, M.C. de Waard, I. van der Pluijm, Y. Ridwan, M.J. Sassen, P. van Nierop, R.C. van der Schors, K.W. Li, J.H. Hoeijmakers, A.B. Smit, R.E. van Kesteren.
Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.
J. Proteome Res. Mar 2;11 (3):1855-67 (2012).

365. S. Bergink, W. Toussaint, M.S. Luijsterburg, C. Dinant, S. Alekseev, J.H. Hoeijmakers, N.P. Dantuma, A.B. Houtsmuller, W. Vermeulen.
Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex
J. Cell Biol. 196(6):681-8 (2012).

366. P. Schwertman, A. Lagarou, D.H. Dekkers, A. Raams, A.C. van der Hoek, C. Laffeber, J.H. Hoeijmakers, J.A. Demmers, M. Fousteri, W. Vermeulen, J.A. Marteijn.
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Nat Genet. 44(5):598-602 (2012) See also News and Views (J. Cleaver)Nat. Genet., 44, 477 8, (2012).

367. D. Das, G.E. Folkers, M. van Dijk, N.G. Jaspers, J.H. Hoeijmakers, R. Kaptein, R. Boelens.
The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.
Structure 20(4):667-75 (2012).

368. C. Nicolaije, K.E. Diderich, S.M. Botter, M. Priemel, J.H. Waarsing, J.S. Day, R.M. Brandt, A.F. Schilling, H. Weinans, B.C. van der Eerden, G.T. van der Horst, J.H. Hoeijmakers, J.P. van Leeuwen.
Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.
PLoS One 7(4):e35246 (2012).

369. M. Durik, M. Kavousi, I. van der Pluijm, A. Isaacs, C. Cheng, K. Verdonk, A.E. Loot, H. Oeseburg, U.M. Bhaggoe, F. Leijten, R. van Veghel, R. de Vries, G. Rudez, R. Brandt, Y.R. Ridwan, E.D. van Deel, M. de Boer, D. Tempel, I. Fleming, G.F. Mitchell, G.C. Verwoert, K.V. Tarasov, A.G. Uitterlinden, A. Hofman, H.J. Duckers, C.M. van Duijn, B.A. Oostra, J.C. Witteman, D.J. Duncker, A.H. Danser, J.H. Hoeijmakers, A.J. Roks.
Nucleotide excision DNA repair is associated with age-related vascular dysfunction.
Circulation 126(4):468-78 (2012).

370. H. Lans, J.H.Hoeijmakers.
Genome stability, progressive kidney failure and aging.
Nat Genet. 44(8):836-8 (2012).

371. S. Gombar, H.J. Jung, F. Dong, B. Calder, G. Atzmon, N. Barzilai, X.L. Tian, J. Pothof, J.H. Hoeijmakers, J. Campisi, J. Vijg, Y. Suh.
Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.
BMC Genomics 13(1):353 (2012).

372. M. van de Ven, J.O. Andressoo, G.T. van der Horst, J.H. Hoeijmakers, J.R. Mitchell.
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.
DNA Repair 11(11):874-83 (2012).

373. H. Menoni, J.H. Hoeijmakers, W. Vermeulen.
Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo.
J. Cell Biol. 199(7):1037-46 (2012).

2013
374. E.L. de Graaf, W.P. Vermeij, M.C. de Waard, Y. Rijksen, I. van der Pluijm, C.C. Hoogenraad, J.H. Hoeijmakers, A.F. Altelaar, A.J. Heck.
Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum.
Mol. Cell Proteomics, 12(5):1350-1362 (2013).

375. A.Y. Maslov, S. Ganapathi, M. Westerhof, W. Quispe, R.R. White, B. van Houten, E. Reiling, M.E. Dollé, H. van Steeg, P. Hasty, J.H. Hoeijmakers, J. Vijg.
DNA damage in normally and prematurely aged mice.
Aging Cell 12(3):467-477 (2013).

376. D. Jaarsma, I. van der Pluijm, G.T.J. van der Horst, J.H.J. Hoeijmakers.
Cockayne syndrome pathogenesis: Lessons from mouse models.
Mech. Ageing & Dev 134(5-6):180-195 (2013).

377. A.F. Theil, J. Nonnekens, B. Steurer, P-O Mari, J. de Wit, C. Lemaitre, J.A. Marteijn, A. Raams, M. Vermeij, J. Essers, J.H. Hoeijmakers, G. Giglia-Mari, W. Vermeulen.
Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
PLOS Genetics 9(4): e1003431 (2013).

378. M.J. Jonker, J.P. Melis, R.V. Kuiper, T.V. van der Hoeven, P.F. Wackers, J. Robinson, G.T. van der Horst, M.E. Dollé, J. Vijg, T.M. Breit, J.H. Hoeijmakers, H. van Steeg.
Life-spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.
Aging Cell 12(5):901-909 (2013).

379. S. Sepe, C. Payan-Gomez, C. Milanese, J.H. Hoeijmakers, P.G. Mastroberardino.
Nucleotide excision repair in chronic neurodegenerative diseases.
DNA Repair 12(8):568-577 (2013).

380. L.M. Uittenboogaard, C. Payan-Gomez, J. Pothof, W. van IJcken, P.G. Mastroberardino, I. van der Pluijm, J.H. Hoeijmakers, M. Tresini.
BACH2: A marker of DNA damage and ageing.
DNA Repair (Amst).12(11):982-992 (2013).

381. H. Lans, J.M. Lindvall, K. Thijssen, A.E. Karambelas, D. Cupac, O. Fensgård, G. Jansen, J. Hoeijmakers, H. Nilsen, W. Vermeulen.
DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals.
Cell Death Differ. 20(12):1709-1718 (2013).

382. B. Schermer, V. Bartels, P. Frommolt, B. Habermann, F. Braun, J.L. Schultze, M. Roodbergen, J.H. Hoeijmakers, B. Schumacher, P. Nürnberg, M.E. Dollé, T. Benzing, R.U. Müller, C.E. Kurschat.
Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular aging.
BMC Genomics 14:559 (2013).

383. M.J. Jonker, J.P. Melis, R.V. Kuiper, T.V. van der Hoeven, P.F. Wackers, J. Robinson, G.T. van der Horst, M.E. Dollé, J. Vijg, T.M. Breit, J.H. Hoeijmakers, H. van Steeg.
Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.
Aging Cell 12(5):901-9 (2013).

384. J.P. Melis, M.J. Jonker, J. Vijg, J.H.J. Hoeijmakers, T.M. Breit, H. van Steeg.
Aging on a different scale – chronological versus pathology-related aging.
Aging 5(10):782-788 (2013).

385. S. Gravina, M.E. Dollé, T. Wang, H. van Steeg, P. Hasty, J.H.J. Hoeijmakers, J. Vijg.
High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice.
PLoS One. 8(9):e73496 (2013).

386. M.T. van Jaarsveld, M.D. Wouters, A.W. Boersma, M. Smid, W.F. van Ijcken, R.H. Mathijssen, J.H.J. Hoeijmakers, J.W. Martens, S. van Laere, E.A. Wiemer, J. Pothof.
DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity.
Mol Oncol. 2013 Dec 31. pii: S1574-7891(13)00183-X (2013).

387. F. Kouzine, D. Wojtowicz, A. Yamane, W. Resch, K.R. Kieffer-Kwon, R. Bandle, S. Nelson, H. Nakahashi, P. Awasthi, L. Feigenbaum, H. Menoni, J.H.J. Hoeijmakers, W. Vermeulen, H. Ge, T.M. Przytycka, D. Levens, R. Casellas.
Global regulation of promoter melting in naïve lymphocytes.
Cell;153(5):988-999 (2013).
2014
388. E. Reiling, M.E. Dollé, S.A. Youssef, M. Lee, B. Nagarajah, M. Roodbergen, P. de With, A. de Bruin, J.H.J. Hoeijmakers, J. Vijg, H. van Steeg, P. Hasty.
The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
PLoS One. 9(4):e93568. doi: 10.1371/journal.pone.0093568 (2014).

389. D.D. Raj, D. Jaarsma, I.R. Holtman, M. Olah, F.M. Ferreira, W. Schaafsma, N. Brouwer, M.M. Meijer, M.C. de Waard MC, I. van der Pluijm, R. Brandt, K.L. Kreft, J.D. Laman, G. de Haan, K.P. Biber, J.H. Hoeijmakers, B.J. Eggen, H.W. Boddeke.
Priming of microglia in a DNA-repair deficient model of accelerated aging.
Neurobiol Aging; Mar 28. pii: S0197-4580(14)00282-6.(Epub ahead of print) (2014).

390. K.W. Derks, J.H.J. Hoeijmakers, J. Pothof.
The DNA damage response: The omics era and its impact.
DNA Repair (Amst). Apr 29. pii: S1568-7864(14)00079-2. (Epub ahead of print) (2014).

391. J.A. Marteijn, H. Lans, W. Vermeulen, J.H.J. Hoeijmakers.
Understanding Nucleotide Excision Repair and its roles in Cancer and Ageing.
Nature Rev. Mol. Cell Biol. 15, 465-481. (2014).

392. W.P. Vermeij, J.H.J. Hoeijmakers, J. Pothof.
Aging: not all DNA damage is equal.
Current Opinion in Genetics & Development; 26C:124-130 (2014).

393. F. Jongbloed, R.W. de Bruin, J.L. Pennings, C. Payan-Gomez, S. van den Engel, C.T. van Oostrom, A. de Bruin, J.H.J. Hoeijmakers, H. van Steeg, J.N. IJzermans and M.E. Dollé.
Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.
Plos One 9(6):e100853 (2014).

394. K.A. Naipal, N.S. Verkaik, N. Ameziane, C.H. van Deurzen, P. ter Brugge, M. Meijers, A.M. Sieuwerts, J.W. Martens, M.J. O'Connor, H. Vrieling, J.H.J. Hoeijmakers, J. Jonkers, R. Kanaar, J.P. de Winter, M.P. Vreeswijk, A. Jager and D.C. van Gent.
Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment.
Clin. Cancer Res. 20(18):4816-4826, (2014).

395. A.F. Theil, J.H.J. Hoeijmakers and W. Vermeulen.
TTDA: Big impact of a small protein.
Exp. Cell Res. pii: S0014-4827, 14, 00277-8 (2014).

396. S. Barnhoorn, L.M. Uittenboogaard, D. Jaarsma, W.P. Vermeij, M. Tresini, M. Weymaere, H. Menoni, R.M. Brandt, M.C. de Waard, S.M. Botter, A.H. Sarker, N.G.J. Jaspers, G.T.J. van der Horst, P.K. Cooper, J.H.J. Hoeijmakers and I. van der Pluijm.
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
PloS Genetics Oct 9;10(10):e1004686 (2014).

397. E.J. Uringa, C. Baldeyron, H. Odijk, E. Wassenaar, W.A. van Cappellen, A. Maas, J.H. Hoeijmakers, W.M. Baarends, R. Kanaar, J. Essers.
A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity.
DNA Repair (Amst). Nov 18;25C:27-40. doi: 10.1016/j.dnarep.2014.11.002. (2014)

398. S.M. Swagemakers, N.G. Jaspers, A. Raams, D. Heijsman, W. Vermeulen, C. Troelstra, A. Kremer, S.E. Lincoln, R. Tearle, J.H. Hoeijmakers, P.J. van der Spek.
Pollitt syndrome patients carry mutation in TTDN1.
Meta Gene. Aug 30;2:616-8. doi: 10.1016/j.mgene.2014.08.001 (2014).

399. M. Demaria, N. Ohtani, S.A. Youssef, F. Rodier, W. Toussaint, J.R. Mitchell, R.M. Laberge, J. Vijg, H. van Steeg, M.E. Dollé, J.H. Hoeijmakers, A. de Bruin, E. Hara, J. Campisi.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Dev Cell. Dec 22;31(6):722-33. doi: 10.1016/j.devcel.2014.11.012. Epub 2014 Dec 11 (2014).

400. A. Bürkle, M. Moreno-Villanueva, J. Bernhard, M. Blasco, G. Zondag, J.H. Hoeijmakers, O. Toussaint, B. Grubeck-Loebenstein, E. Mocchegiani, S. Collino, E.S. Gonos, E. Sikora, D. Gradinaru, M. Dollé, M. Salmon, P. Kristensen, H.R. Griffiths, C. Libert, t. Grune, N. Breusing, A. Simm, C. Franceschi, M. Capri, D. Talbot, P. Caiafa, B. Friguet, P.E. Slagboom, A. Hervonen, M. Hurme, R. Aspinall.
MARK-AGE biomarkers of ageing.
Mech Ageing Dev. Mar 24. pii: S0047-6374(15)00031-7. doi: 10.1016/j.mad.2015.03.006. (2014).
2015
401. S.L. MacRae, Q. Zhang, C. Lemetre, I. Seim, R.B. Calder, J.H. Hoeijmakers, Y. Suh, V.N. Gladyshev, A. Seluanov, V. Gorbunova, J. Vijg, Z.D. Zhang.
Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.
Aging Cell. Apr;14(2):288-91. doi: 10.1111/acel.12314. Epub 2015 Jan 28. PMID: 25645816 (2015)

402. K.A. Naipal, A. Raams, S.T. Bruens, I. Brandsma, N.S. Verkaik, N.G. Jaspers, J.H. Hoeijmakers, G.J. van Leenders, J. Pothof, R. Kanaar, J. Boormans, D.C. van Gent.
Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.
PLoS One 10(4):e0126029. doi: 10.1371/journal.pone.0126029. eCollection (2015).

403. K.W. Derks, B. Misovic, M.C. van den Hout, C.E. Kockx, C.P. Gomez, R.W. Brouwer, H. Vrieling, J.H. Hoeijmakers, W.F. van IJcken, J. Pothof.
Deciphering the RNA landscape by RNAome sequencing.
RNA Biol. 12(1):30-42. doi: 10.1080/15476286.2015.1017202 (2015).

404. M. Faridounnia, H. Wienk, L. Kovačič, G.E. Folkers, N.G. Jaspers, R. Kaptein, J.H. Hoeijmakers, R. Boelens.
The Cerebro-Oculo-Facio-Skeletal (COFS) Syndrome point mutation F231L in the ERCC1 DNA repair protein causes dissociation of the ERCC1-XPF complex.
J Biol Chem. Jun 17. pii: jbc.M114.635169. [Epub ahead of print] (2015).

405. F. Kruiswijk, S.C. Hasenfuss, R. Sivapatham, M.P. Baar, D. Putavet, K.A. Naipal, N.J. van den Broek, W. Kruit, P.J. van der Spek, D.C. van Gent, A.B. Brenkman, J. Campisi, B.M. Burgering, J.H. Hoeijmakers, P.L. de Keizer.
Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.
Oncoge ne. 2015 Aug 17. doi: 10.1038/onc.2015.282. [Epub ahead of print]

406. J.A. Marteijn, J.H. Hoeijmakers, W. Vermeulen.
Check, Check ...Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair.
Molecular Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.

407. P.K. Niño, M. Durik, A.H. Danser, R. de Vries, U.M. Musterd-Bhaggoe, M.E. Meima, M. Kavousi, M. Ghanbari, J.H. Hoeijmakers, C.F. O'Donnell, N. Franceschini, G.M. Janssen, J.G. de Mey, Y. Liu, C.M. Shanahan, O.H. Franco, A. Dehghan and A.J. Roks.
Phosphodiesterase 1 regulation is a key mechanism in vascular aging.
Clin Sci (Lond). 2015 Dec 1;129(12):1061-75.

408. W.P. Vermeij, J.H.J. Hoeijmakers and J. Pothof,
Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.
Annu Rev Pharmacol Toxicol. 2015 Oct 28. [Epub ahead of print], PMID: 26514200

409. M. Tresini, D.O. Warmerdam, P. Kolovos, L. Snijder, M.G. Vrouwe, J.A.A. Demmers, W.F. van IJcken, F.G. Grosveld, R.H. Medema, J.H.J. Hoeijmakers , L.H.F. Mullenders, W. Vermeulen and J.A. Marteijn.
The core spliceosome as a target and effector of non-canonical ATM signaling.
Nature. Jul 2;523:53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24. (2015)

410. K.S.Trego, T. Groesser, A.R. Davalos, A.C. Parplys, W. Zhao, M.R. Nelson, A. Hlaing, B. Shih, B. Rydberg, J.M. Pluth, W-S. Tsai, J.H.J. Hoeijmakers, P. Sung, C. Wiese, J. Campisi, P.K. Cooper. Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Molec. Cell 2016 Jan 27. pii: S1097-2765(15)01008-4. doi: 10.1016/j.molcel.2015.12.026. [Epub ahead of print] PMID: 26833090
2016
411. H. Matsumura, Y. Mohri, N. Thanh Binh, H. Morinaga, M. Fukuda, M. Ito, S. Kurata, J.H.J. Hoeijmakers, and E.K. Nishimura.
Hair follicle aging is driven by transepidermal elimination of stem cells via Col17A1 proteolysis.
Science Feb 5;351(6273):aad4395. doi: 10.1126/science.aad4395. Epub 2016 Feb 4. PMID: 26912707 (see also Lei M, Chuong CM. STEM CELLS. Aging, alopecia, and stem cells. Science, 2016 Feb 5;351(6273):559-60. doi: 10.1126/science.aaf1635).

.

412. F. Braun, M.M Rinschen, V. Bartels, P. Frommolt, B. Habermann, J.H. Hoeijmakers, B. Schumacher, M.E. Dollé ME, R.U., Müller, T. Benzing, B. Schermer and C.E. Kurschat.
Altered lipid metabolism in the aging kidney identified by three layered omic analysis.
Aging (Albany NY). 2016 Feb 16. [Epub ahead of print] PMID: 26886165

413. W.E. Visser, C.R. Bombardieri, C. Zevenbergen, S. Barnhoorn, A. Ottaviani, I. van der Pluijm, R. Brandt, E. Kaptein, R. van Heerebeek, H. van Toor, G.A. Garinis, R.P. Peeters, M. Medici, W. van Ham, W.P. Vermeij, M.C. de Waard, R.R. de Krijger, A. Boelen, J. Kwakkel, J.J. Kopchick, E.O. List, J.P. Melis, V.M. Darras, M.E. Dollé, G.T. van der Horst, J.H. Hoeijmakers and T.J. Visser.
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.
PLoS One. 2016 Mar 8;11(3):e0149941. doi: 10.1371/journal.pone.0149941. eCollection 2016. PMID: 26953569

414. S. Sepe, C. Milanese, S. Gabriels, K.W. Derks, C. Payan-Gomez, W.F. van IJcken, Y.M. Rijksen, A.L. Nigg, S. Moreno S, Cerri S, Blandini F, Hoeijmakers JH, and Mastroberardino PG.
Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson's Disease.
Cell Rep. 2016 May 31;15(9):1866-75. doi: 10.1016/j.celrep.2016.04.071. Epub 2016 May 19. PMID: 27210754

415. W.P. Vermeij, M.E.T. Dollé, E. Reiling, D. Jaarsma, C. Payan-Gomez, C.R. Bombardieri, H. Wu, A.J.M. Roks, S.M. Botter, B.C. van der Eerden, S.A.Youssef, R.V. Kuiper, B. Nagarajah, C.T. van Oostrom, R.M.C. Brandt, S. Barnhoorn, S. Imholz, J.L.A. Pennings, A. de Bruin, Á. Gyenis, J. Pothof, J. Vijg, H. van Steeg and J.H.J. Hoeijmakers.
Restricted diet delays accelerated aging and genomic stress in DNA repair deficient mice.
Nature 537, 427-431 (Sept 15, 2016, see also accompanying Nature 'News and Views' of Oshima and Martin).

416. J.S.E. Laven, J.A. Visser, A.G.Uitterlinden, W.P.Vermeij and J.H.J. Hoeijmakers,
Menopause: Genome stability as new paradigm.
Maturitas (October 2016; 92, Pages 15–23.)

417. A.A. van Beek, B. Sovran, F. Hugenholtz, B. Meijer, J.A. Hoogerland, V. Mihailova, C. van der Ploeg, C. Belzer, M.V. Boekschoten, J.H. Hoeijmakers, W.P. Vermeij, P. de Vos, J.M. Wells, P.J. Leenen, C. Nicoletti, R.W. Hendriks, H.F. Savelkoul.
Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/Δ7 Mice.
Front Immunol. 2016 Oct 7;7:408. PMID: 27774093
2017
418. J. Nonnekens and J.H.J. Hoeijmakers.
After surviving cancer, what about late life effects of the cure?
EMBO Mol Med. 2017 Jan;9(1):4-6. doi: 10.15252/emmm.201607062. PMID: 27852619

419. F. Jongbloed, T.C. Saat, M. Verweij, C. Payan-Gomez, J.H. Hoeijmakers, S. van den Engel, C.T. van Oostrom, G. Ambagtsheer, S. Imholz, J.L. Pennings, H. van Steeg, J.N. IJzermans, M.E. Dollé, R.W. de Bruin.
A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.
Sci Rep. 2017 Jan 19;7:40901. doi: 10.1038/srep40901. PMID: 28102354

420. J.H. Cole, J. Underwood, M.W. Caan, D. De Francesco, R.A. van Zoest, R. Leech, F.W. Wit, P. Portegies, G.J. Geurtsen, B.A. Schmand, M.F. Schim van der Loeff, C. Franceschi, C.A. Sabin, C.B. Majoie, A. Winston, P. Reiss, D.J. Sharp; COBRA collaboration.
Increased brain-predicted aging in treated HIV disease.
Neurology. 2017 Apr 4;88(14):1349-1357. doi: 10.1212/WNL.0000000000003790. Epub 2017 Mar 3. PMID: 28258081

421. M.P. Baar, R.M. Brandt, D.A. Putavet, J.D. Klein, K.W. Derks, B.R. Bourgeois, S. Stryeck, Y. Rijksen, H. van Willigenburg, D.A. Feijtel, I. van der Pluijm, J. Essers, W.A. van Cappellen, W.F. van IJcken, A.B. Houtsmuller, J. Pothof, R.W. de Bruin, T. Madl, J.H. Hoeijmakers, J. Campisi, P.L. de Keizer.
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell 169, 132-147 (2017) e16. doi: 10.1016/j.cell.2017.02.031.PMID: 28340339

422. A.A. van Beek, F. Hugenholtz, B. Meijer, B. Sovran, O. Perdijk, W.P. Vermeij, R.M.C. Brandt, S. Barnhoorn, J.H.J. Hoeijmakers, P. de Vos, ; P.J.M. Leenen, R.W. Hendriks and H.F.J. Savelkoul,
Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1(-/Delta 7) mice.
J. of Leukocyte Biology 101, 811-821, 2017, DOI: 10.1189/jlb.1HI0216-062RR

423. M. Ogrodnik, S. Miwa, S, T. Tchkonia, D. Tiniakos, C.L. Wilson, A. Lahat, C.P. Day, A. Burt, A. Palmer, Q.M. Anstee, S.N. Grellscheid, J.H.J. Hoeijmakers, S. Barnhoorn, D.A. Mann, T.G. Bird, W.P. Vermeij, J.L. Kirkland, J.F. Passos, T. von Zglinicki and D. Jurk
Cellular senescence drives age-dependent hepatic steatosis
Nature Comm. 8, (June, 13, 2017), Art. Number: 15691, DOI: 10.1038/ncomms15691

424. G. La Fata, N. van Vliet, S. Barnhoorn, R.M. C. Brandt, S. Etheve, E. Chenal, C. Grunenwald, N. Seifert, P. Weber, J.H.J. Hoeijmakers, M.H. Mohajeri, W.P. Vermeij.
Vitamin E Supplementation Reduces Cellular Loss in the Brain of a Premature Aging Mouse Model.
J Prev Alzheimers Dis. 2017;4(4):226-235. doi: 10.14283/jpad.2017.30.

425. I.K. Mandemaker, L. van Cuijk, R.C. Janssens, H. Lans, K. Bezstarosti, J.H. Hoeijmakers, J.A.Demmers, W. Vermeulen, J.A. Marteijn.
DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.
Sci Rep. 2017 Nov 10;7(1):15353. doi: 10.1038/s41598-017-15194-y.

426. A.F. Theil, I.K. Mandemaker, E. van den Akker, S.M.A. Swagemakers, A. Raams, T. Wüst, J.A. Marteijn, J.C. Giltay, R.M. Colombijn, U. Moog, U. Kotzaeridou, M. Ghazvini, M. von Lindern, J.H.J. Hoeijmakers, N.G.J. Jaspers, P.J. van der Spek, W. Vermeulen.
Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.
Hum Mol Genet. 2017 Dec 1;26(23):4689-4698. doi: 10.1093/hmg/ddx351.

427. H. Wu, B.S. van Thiel, P.K. Bautista-Niño, E. Reiling, M. Durik, F.P.J. Leijten, Y. Ridwan, R.M.C. Brandt, H. van Steeg, M.E.T. Dollé, W.P. Vermeij, J.H.J. Hoeijmakers, J. Essers, I. van der Pluijm, A.H.J. Danser, A.J.M. Roks.
Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1Δ/- mice.
Clin Sci (Lond). 2017 Jul 13;131(15):1941-1953. doi: 10.1042/CS20170026. Print 2017 Aug 1.
2018
428. L.J. Niedernhofer, A.U. Gurkar, Y. Wang, J. Vijg, J.H.J. Hoeijmakers, P.D. Robbins.
Nuclear Genomic Instability and Aging.
Annu Rev Biochem. 2018 Jun 20;87:295-322. doi: 10.1146/annurev-biochem-062917-012239. PMID: 29925262

429. C. Milanese, S. Cerri, A. Ulusoy, S.V. Gornati, A. Plat, S. Gabriels, F. Blandini, D.A. Di Monte, J.H. Hoeijmakers, P.G. Mastroberardino.
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease.
Cell Death Dis. 2018 Jul 26;9(8):818. doi: 10.1038/s41419-018-0848-7. PMID: 30050065

430. I.K. Mandemaker, M.E. Geijer, I. Kik, K. Bezstarosti, E. Rijkers, A. Raams, R.C. Janssens, H. Lans, J.H. Hoeijmakers, J.A. Demmers, W. Vermeulen, J.A. Marteijn.
DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.
EMBO Rep. 2018 Aug 13. pii: e45566. doi: 10.15252/embr.201745566. [Epub ahead of print] PMID: 30104204

431. C. Ribeiro-Silva, Ö.Z. Aydin, R. Mesquita-Ribeiro, J. Slyskova, A. Helfricht, J.A. Marteijn, J.H.J. Hoeijmakers, H. Lans, W. Vermeulen.
DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.
Nat Commun. 2018 Oct 4;9(1):4067. doi: 10.1038/s41467-018-06402-y. PMID: 30287812
2019
432. Alyodawi, K., Vermeij, W.P., Omairi, S., Kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R.M.C., Barnhoorn, S., van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T.B., Hoeijmakers, J.H.J., Patel, K. Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling.
J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):662-686. doi: 10.1002/jcsm.12404. Epub 2019 Mar 27. PMID: 30916493

433. Jager, M., Blokzijl, F. Kuijk, E., Bertl, J., Vougioukalaki, M., Janssen, R., Besselink, N., Boymans, S., de Ligt, J., Pedersen, J.S., Hoeijmakers, J., Pothof, J., van Boxtel, R., Cuppen, E.
'Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer'
Genome Research, 2019 Jul;29(7):1067-1077. doi: 10.1101/gr.246223.118. Epub 2019 Jun 20.

434. Theil, A.F., Botta, E., Raams, A., Smith, D.E.C., Mendes, M.I., Caligiuri, G., Giachetti, S., Bione, S., Carriero, R., Liberi, G., Zardoni, L., Swagemakers, S.M.A., Salomons, G.S., Sarasin, A., Lehmann, A., van der Spek, P.J., Ogi, T., Hoeijmakers, J.H.J., Vermeulen, W., Orioli, D.
Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype
Am J Hum Genet. 2019 Aug 1;105(2):434-440. doi: 10.1016/j.ajhg.2019.06.017. PMID: 31374204

435. Lans H, Hoeijmakers JHJ, Vermeulen W, Marteijn JA.
The DNA damage response to transcription stress.
Nat Rev Mol Cell Biol. 2019 Sep 26. doi: 10.1038/s41580-019-0169-4. [Epub ahead of print] PMID: 31558824

436. Milanese C, Bombardieri CR, Sepe S, Barnhoorn S, Payán-Goméz C, Caruso D, Audano M, Pedretti S, Vermeij WP, Brandt RMC, Gyenis A, Wamelink MM, de Wit AS, Janssens RC, Leen R, van Kuilenburg ABP, Mitro N, Hoeijmakers JHJ, Mastroberardino PG.
DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering.
Nat Commun. 2019 Oct 25;10(1):4887. doi: 10.1038/s41467-019-12640-5.
PMID: 31653834

437. Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J.
Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
Aging Cell. 2019 Nov 18:e13072. doi: 10.1111/acel.13072. [Epub ahead of print]
PMID: 31737985

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