Since 2020

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Publications since 2022

2020
438. Bautista-Niño PK, Portilla-Fernandez E, Rubio-Beltrán E, van der Linden JJ, de Vries R, van Veghel R, de Boer M, Durik M, Ridwan Y, Brandt R, Essers J, Menzies RI, Thomas R, de Bruin A, Duncker DJ, van Beusekom HMM, Ghanbari M, Hoeijmakers JHJ, Sedlacek R, Touyz RM, Montezano AC, van der Pluijm I, Danser AHJ, Haanes KA, Roks AJM
Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction.
Clin Sci (Lond). 2020 Apr 17;134(7):727-746. doi: 10.1042/CS20190124.
PMID: 32202295

439. Jongbloed F, de Bruin RWF, Steeg HV, Beekhof P, Wackers P, Hesselink DA, Hoeijmakers JHJ, Dollé MET, IJzermans JNM
Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients.
Aging (Albany NY). 2020 Jul 11;12(13):12441-12467. doi: 10.18632/aging.103619. Epub 2020 Jul 11. PMID: 32652516

440. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.
ARDD 2020: from aging mechanisms to interventions.
Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. PMID: 33378272
2021
441. Vermeij WP, Hoeijmakers JHJ.
Base editor repairs mutation found in the premature-ageing syndrome progeria.
Nature. 2021 Jan;589(7843):522-524. doi: 10.1038/d41586-020-03573-x.
PMID: 33408358

442. Birkisdóttir MB, Jaarsma D., Brandt RMC, Barnhoorn S, van Vliet N, Imholz S, van Oostrom CT,
Nagarajah B, Portilla Fernández E., Roks AJM, Elgersma Y, van Steeg H, Pennings JLA, Hoeijmakers JHJ, Vermeij WP, Dollé MTE.
Unlike dietary restriction rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA-repair deficient mice.
Aging Cell. 2021 Jan 23:e13302. doi: 10.1111/acel.13302. Online ahead of print.
PMID: 33484480

443. Botta E, Theil AF, Raams A, Caligiuri G, Giachetti S, Bione S, Accadia M, Lombardi A, Smith DEC, Mendes MI, Swagemakers SMA, van der Spek PJ, Salomons GS, Hoeijmakers JHJ, Yesodharan D, Nampoothiri S, Ogi T, Lehmann AR, Orioli D, Vermeulen W.
Protein instability associated with AARS1 and MARS1 mutations causes Trichothiodystrophy.
Hum Mol Genet. 2021 Apr 28:ddab123. doi: 10.1093/hmg/ddab123. Online ahead of print.
PMID: 33909043

444. Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ.
The central role of DNA damage in the ageing process.
Nature. 2021 Apr;592(7856):695-703. doi: 10.1038/s41586-021-03307-7. Epub 2021 Apr 28.
PMID: 33911272 Review.

445. Hoeijmakers JHJ. Expert opinion on 'Base editor treats progeria in mice'.
Nature Online June 18, 2021.
446. Van't Sant LJ, White JJ, Hoeijmakers JHJ, Vermeij WP, Jaarsma D (2021).
In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration.
Acta Neuropathol Commun. 2021 May 21;9(1):94. doi: 10.1186/s40478-021-01200-y.
PMID: 34020718; PMCID: PMC8139001.

447. Van Den Boogaard W, Smit K, Brandt R, Barnhoorn S, Rijksen Y, Komninos, D, Van Den Heuvel-Eibrink M, Hoeijmakers J, Vermeij, W.
Pre-Therapy Fasting Reduces Acute and Late-Life Cisplatin Toxicities.
Pediatric Blood & Cancer 68, Pages: S353-S353 Meeting abstract: PV0426: Nov. 2021.
2022
448. Vougioukalaki M, Demmers J, Vermeij WP, Baar M, Bruens S, Magaraki A, Kuijk E, Jager M, Merzouk S, Brandt RMC, Kouwenberg J, Van Boxtel R, Cuppen E, Pothof J, Hoeijmakers JHJ. Different responses to DNA damage determine ageing differences between organs.
Aging Cell 2022 (accepted)

449. Christiaan A.J. Oudmaijer, Winnie M.C. van den Boogaard, Daphne S. J. Komninos, Emma J. Verwaaijen, Hanneke M. van Santen, Marc R. Lilien, Jan H.J. Hoeijmakers, Marc H.W. Wijnen, Wilbert P. Vermeij, Marry M. van den Heuvel-Eibrink.
Fasting Intervention for children with Unilateral Renal Tumours to reduce Toxicity.
Frontiers in Pediatrics, 2022, Manuscript ID: 828615 (accepted)

450. Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shi-Qing Cai, Brian Chen, Maria Ermolaeva, Collin Ewald, Luigi Ferrucci, Maria Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch-Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James Kirkland, Mikael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter Longo, Yu-Xuan Lu, Michael MacArthur, Andrea Maier, Christina Manakanatas, Sarah Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegué, Michael Petr, James Peyer, Dina Radenkovic, Thomas Rando, Suresh Rattan, Christian Riedel, Karl Lenhard Rudolph, Alice Ruixue Ai, Manuel Serrano, Björn Schumacher, David Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, and Morten Scheibye-Knudsen.
Aging Research and Drug Discovery. Aging (accepted) #: 013958.

451. Oudmaijer CAJ, Minnee RC, Pol RA, van den Boogaard WMC, Komninos DSJ, van de Wetering J, van Heugten MH, Hoorn EJ, Sanders JSF, Hoeijmakers JHJ, Vermeij WP and IJzermans JNM
Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial.
Trials (2022) 23:18 https://doi.org/10.1186/s13063-021-05950-x

452. Gyenis A, Chang J, Demmers JJPG, Bruens ST, Barnhoorn S, Brandt R, Baar MP, Raseta M, Derks KWJ, Hoeijmakers JHJ, Pothof J.
Genome-wide transcription stalling by DNA damage shapes the transcriptome in aging.
Nature Genetics (accepted, pending minor revision)

453. Gustavo Satoru Kajitani, Carolina Quayle, Camila Carrião Machado Garcia, Wesley Luzetti Fotoran, Juliana Fernandes Rossi dos Santos, Gijsbertus TJ van der Horst, Jan HJ Hoeijmakers, Carlos Frederico Martins Menck.
Photorepair of either CPD or 6-4PP DNA lesions in basal keratinocytes attenuates ultraviolet-induced skin effects in Nucleotide Excision Repair deficient mice.
Frontiers in Immunology, section Molecular Innate Immunity, Manuscript ID: 800606 (accepted) https://doi.org/10.3389/fimmu.2022.800606

454. Oudmaijer CAJ, Berk KA, van der Louw EJTM, de Man RA, van der Lelij A-J, Hoeijmakers JHJ, IJzermans JNM.
KETOgenic diet therapy in patients with HEPatocellular adenoma, study protocol of a matched cohort study. bmjopen-2021-053559.R1 (2022, Accepted)

455. Martine de Boer; Maaike te Lintel Hekkert; Jiang Chang; Bibi S. van Thiel; Leonie Martens; Maxime M. Bos; Marion G.J. de Kleijnen; Yanto Ridwan; Yanti Octavia; Elza D. van Deel; Lau A. Blonden; Renata M.C. Brandt; Sander Barnhoorn; Paula K. Bautista-Niño; Ilona Krabbendam-Peters; Rianne Wolswinkel; Banafsheh Arshi; Mohsen Ghanbari; Christian Kupatt; Leon J. de Windt; A. H. Jan Danser; Ingrid van der Pluijm; Carol Ann Remme; Monika Stoll; Joris Pothof; Anton J.M. Roks; Maryam Kavousi; Jeroen Essers; Jolanda van der Velden; Jan H.J. Hoeijmakers; Dirk J. Duncker.
DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice.
BRIC, submitted

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