Schumacher Lab Publications

Mitigating age-related somatic mutation burden

Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K.
Trends Mol Med. 2023 Apr 28:S1471-4914(23)00072-2.
doi: 10.1016/j.molmed.2023.04.002. Online ahead of print.

The DREAM complex functions as conserved master regulator of somatic DNA repair capacities.

Bujarrabal A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi G, Garinis G, Schumacher B.
Nat Struct Mol Biol. 2023 Mar 23.
https://doi.org/10.1038/s41594-023-00942-8

Short-Term UVB Irradiation Leads to Persistent DNA Damage in Limbal Epithelial Stem Cells, Partially Reversed by DNA Repairing Enzymes.

Volatier T, Schumacher B, Meshko B, Hadrian K, Cursiefen C, Notara M.
Biology (Basel). 2023 Feb 7;12(2):265.
https://doi.org/10.3390/biology12020265

The novel role of lymphatic vessels in the pathogenesis of ocular diseases.

Clahsen T, Hadrian K, Notara M, Schlereth SL, Howaldt A, Prokosch V, Volatier T, Hos D, Schroedl F, Kaser-Eichberger A, Heindl LM, Steven P, Bosch JJ, Steinkasserer A, Rokohl AC, Liu H, Mestanoglu M, Kashkar H, Schumacher B, Kiefer F, Schulte-Merker S, Matthaei M, Hou Y, Fassbender S, Jantsch J, Zhang W, Enders P, Bachmann B, Bock F, Cursiefen C.
Prog Retin Eye Res. 2023 Feb 7:101157.
https://doi.org/10.1016/j.preteyeres.2022.101157

Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling
Selle J, Bohl K, Höpker K, Wilke R, Dinger K, Kasper P, Abend B, Schermer B, Müller R, Kurschat C, Nüsken K, Nüsken E, Meyer D, Savai Pullamsetti S, Schumacher B, Dötsch J, Alejandre Alcazar M,
Int. J. Mol. Sci. 2023, 24(3), 2508;
https://doi.org/10.3390/ijms24032508

Inheritance of paternal DNA damage by histone-mediated repair restriction.

Wang, S., Meyer, D.H. & Schumacher, B.
Nature 2023 Jan;613(7943):365-374.
https://doi.org/10.1038/s41586-022-05544-w

Sensory neurons safeguard from mutational inheritance by controlling the CEP-1/p53-mediated DNA damage response in primordial germ cells

Uszkoreit S, Meyer DH, Rechavi O, Schumacher B.

Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice.

Kasper P, Selle J, Vohlen C, Wilke R, Kuiper-Makris C, Klymenko O, Bae-Gartz I, Schömig C, Quaas A, Schumacher B, Demir M, Bürger M, Lang S, Martin A, Steffen HM, Goeser T, Dötsch J, Alcazar MAA.

The p53 network: cellular and systemic DNA damage responses in cancer and aging.

Vaddavalli PL, Schumacher B.
The p53 network: cellular and systemic DNA damage responses in cancer and aging.
Trends Genet. 2022 Jun;38(6):598-612. doi: 10.1016/j.tig.2022.02.010. Epub 2022 Mar 25.
https://pubmed.ncbi.nlm.nih.gov/35346511/