Schumacher Lab Publications

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Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice.

Kasper P, Selle J, Vohlen C, Wilke R, Kuiper-Makris C, Klymenko O, Bae-Gartz I, Schömig C, Quaas A, Schumacher B, Demir M, Bürger M, Lang S, Martin A, Steffen HM, Goeser T, Dötsch J, Alcazar MAA.

The p53 network: cellular and systemic DNA damage responses in cancer and aging.

Vaddavalli PL, Schumacher B.
The p53 network: cellular and systemic DNA damage responses in cancer and aging.
Trends Genet. 2022 Jun;38(6):598-612. doi: 10.1016/j.tig.2022.02.010. Epub 2022 Mar 25.
https://pubmed.ncbi.nlm.nih.gov/35346511/

UV Protection in the Cornea: Failure and Rescue

Volatier T, Schumacher B, Cursiefen C, Notara M.
UV Protection in the Cornea: Failure and Rescue.
Biology (Basel). 2022 Feb 10;11(2):278. doi: 10.3390/biology11020278.
https://pubmed.ncbi.nlm.nih.gov/35205145/

Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.

Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB.
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.
Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7.
https://pubmed.ncbi.nlm.nih.gov/35136057/

Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.

Soltanmohammadi N, Wang S, Schumacher B.
Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.
Nat Commun. 2022 Feb 4;13(1):701. doi: 10.1038/s41467-022-28225-8.
https://www.nature.com/articles/s41467-022-28225-8

Meeting Report: Aging Research and Drug Discovery

Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golato T, Gorbunova V, Hoejimakers J, Houtkooper RH, Jager S, Jaksch F, Janssens G, Jensen MB, Kaeberlein M, Karsenty G, de Keizer P, Kennedy B, Kirkland JL, Kjaer M, Kroemer G, Lee KF, Lemaitre JM, Liaskos D, Longo VD, Lu YX, MacArthur MR, Maier AB, Manakanatas C, Mitchell SJ, Moskalev A, Niedernhofer L, Ozerov I, Partridge L, Passegué E, Petr MA, Peyer J, Radenkovic D, Rando TA, Rattan S, Riedel CG, Rudolph L, Ai R, Serrano M, Schumacher B, Sinclair DA, Smith R, Suh Y, Taub P, Trapp A, Trendelenburg AU, Valenzano DR, Verburgh K, Verdin E, Vijg J, Westendorp RGJ, Zonari A, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.
Meeting Report: Aging Research and Drug Discovery
Aging (Albany NY). 2022 Jan 28;14(2):530-543. doi: 10.18632/aging.203859. Epub 2022 Jan 28
doi.org/10.18632/aging.203859

Molecular pagthology of rare progeroid diseases

Rieckher M, Garinis GA, Schumacher B.
Molecular pagthology of rare progeroid diseases
Trends Mol Med. 2021 Jul 13;S1471-4914(21)00178-7.
https://doi.org/10.1016/j.molmed.2021.06.011

The central role of DNA damage in ageing process.

Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ.
The central role of DNA damage in ageing process.
Nature. 592, 695-703 (2021). https://doi.org/10.1038/s41586.021.03307-07

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